Dantrolene sodium
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Dantrolene sodium 속성
- 녹는점
- >230°C
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO(약간), 에틸아세테이트(약간, 가열, 초음파 처리)에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 노란색에서 진한 노란색까지
- CAS 데이터베이스
- 24868-20-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | 22-24/25 | ||
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| WGK 독일 | 2 | ||
| RTECS 번호 | MU3875000 | ||
| HS 번호 | 2934990002 |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Dantrolene sodium C화학적 특성, 용도, 생산
화학적 성질
Orange Powder용도
Dantrolene Sodium Salt Hemiheptahydrate is a muscle relaxant (skeletal). Used in the treatment of malignant hyperthermia.정의
ChEBI: A hydrate which is the hemiheptahydrate of anhydrous dantrolene sodium.Biological Functions
Dantrolene sodium (Dantrium) is used in the treatment of spasticity due to stroke, spinal injury, multiple sclerosis, or cerebral palsy. It is also the drug of choice in prophylaxis or treatment of malignant hyperthermia.Susceptibility to malignant hyperthermia is due to a rare genetic defect that allows Ca++ release from the sarcoplasmic reticulum to open more easily and close less readily than normal. This leads to a high level of Ca++ in the sarcoplasm, which produces muscle rigidity, oxygen consumption, and heat. Dantrolene acts by blocking Ca++ release from the sarcoplasmic reticulum and uncoupling excitation from contraction.
Dantrolene is active orally, although its absorption is slow and incomplete. Its biological half-life (t1/2) is 8.7 hours in adults. The drug is metabolized by liver microsomal enzymes and is eliminated in the urine and bile. It is given IV when treating an attack of malignant hyperthermia. The most prominent and often limiting feature of dantrolene administration is dose-dependent muscle weakness. Other side effects are drowsiness, dizziness, malaise, fatigue, and diarrhea. Symptomatic hepatitis is reported in 0.5% of patients receiving it and fatal hepatitis in up to 0.2%. Contraindications include respiratory muscle weakness and liver disease. It is suggested that patients on dantrolene therapy be given regular liver function tests.
Dantrolene sodium 준비 용품 및 원자재
원자재
준비 용품
Dantrolene sodium 공급 업체
글로벌( 166)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
| Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 |
sales01@whmonad.com | CHINA | 992 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 27945 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; |
info@afinechem.com | China | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9330 | 58 |