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락타시스틴

락타시스틴 구조식 이미지

카스 번호:: 133343-34-7

한글명:: 락타시스틴

동의어(한글):: 락타시스틴

상품명:: LACTACYSTIN

동의어(영문):: Lacta;Aids008388;LACTACYSTIN;Aids-008388;(+)-LACTACYSTIN;LACTACYSTIN (NATIVE);LACTACYSTIN USP/EP/BP;LACTACYSTIN, SYNTHETIC;LACTACYSTIN, STREPTOMYCES SP;S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL

CBNumber:: CB5136696

분자식:: C15H24N2O7S

포뮬러 무게:: 376.43

MOL 파일:: 133343-34-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 118

락타시스틴 속성

녹는점: 233-235°C dec.

끓는 점: 714.9±60.0 °C(Predicted)

밀도: 1.367±0.06 g/cm3(Predicted)

저장 조건: -20°C

용해도: DMSO(최대 20mg/ml), 물(최대 10mg/ml) 또는 에탄올(최대 1mg/ml)에 용해됩니다.

물리적 상태: 가루

산도 계수 (pKa): 3.11±0.10(Predicted)

색상: 흰색에서 황백색까지

수용성: Soluble to 10 mM in water

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 1개월 동안 보관할 수 있습니다. 물에 용해된 용액은 안정적이지 않으므로 영업일 기준으로 하루 안에 사용해야 합니다. 수용액은 보관하면 안 됩니다.

안전

WGK 독일	3

락타시스틴 C화학적 특성, 용도, 생산

개요

Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 μM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.

화학적 성질

White Powder

용도

Lactacystin has been used:

as a proteasome inhibitor to inhibit protein degradation
to inhibit proteasomal activity of cells for live cell imaging
to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
to provide unilateral injection to animals to induce nigrostriatal lesions

정의

ChEBI: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.

일반 설명

Lactacystin is an antibiotic?and a metabolite of Streptomyces?spp.

락타시스틴 준비 용품 및 원자재

원자재

준비 용품

락타시스틴 공급 업체

글로벌( 118)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27588	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

락타시스틴 관련 검색:

L-시스테인 CLASTO-LACTACYSTIN,Clasto-lactacystin -Lactone, Omuralide,Clasto-lactacystin b-Lactone, Omuralide,CLASTO-LACTACYSTIN B-LACTONE MG-132 (+)-LACTACYSTIN ALLYL ESTER,LACTACYSTIN ALLYL ESTER MG-115 N-PROPYL 3-MERCAPTOPROPIONATE 3,3'-THIODIPROPANOL S-Butyl-D-cysteine dacisteine (S)-4-Hydroxy-2-pyrrolidinone Fudosteine S-Methyl 2-methylthiobutyrate LACTACYSTIN N-ACETYL-S-(3-HYDROXYPROPYL)CYSTEINE 5,5-Dimethyl-2-pyrrolidinone clasto-lactacystin β-lactone,LACTACYSTIN, CLASTO-, BETA-LACTONE,CLASTO-LACTACYSTIN BETA-LACTONE S-METHYL 4-METHYLPENTANETHIOATE 5-HYDROXYMETHYL-3-METHYLPYRROLIDIN-2-ONE