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(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid C화학적 특성, 용도, 생산
용도
(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid can be used as Ledipasvir Intermediate, mainly used in laboratory R&D process and chemical production process.
Synthesis
Na2CO3 (1.83 g, 17.2 mmol) was added to an aq solution of NaOH (33 mL of 1 M/H2O, 33 mmol) and L-valine (3.900 g, 33.29 mmol) and the resulting solution was cooled with ice-water bath. Methyl chloroformate (2.8 mL, 36.1 mmol) was added dropwise, the cooling bath was removed and the reaction mixture was stirred at ambient temperature for 3.25 h. The reaction mixture was washed with ether (3x17 mL), and the aqueous phase was cooled with ice-water bath and acidified with conc HCl to a pH of 1-2, and extracted with CH2Cl2 (3x17 mL). The organic phase was dried (anhyd MgSO4), filtered, and concentrated in vacuo. Cap-1 as a white solid (5.00 g, 86%).
(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 준비 용품 및 원자재
원자재
준비 용품
(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 공급 업체
