Cobicistat
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Cobicistat 속성
- 녹는점
- 50-54°C
- 끓는 점
- 974.5±65.0 °C(Predicted)
- 밀도
- 1.228±0.06 g/cm3 (20 ºC 760 Torr)
- 저장 조건
- Hygroscopic, Refrigerator, under inert atmosphere
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.86±0.46(Predicted)
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
- InChIKey
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N
- SMILES
- C(OCC1SC=NC=1)(=O)N[C@@H](CC1=CC=CC=C1)CC[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCN1CCOCC1)NC(=O)N(C)CC1=CSC(C(C)C)=N1
안전
Cobicistat C화학적 특성, 용도, 생산
개요
Cobicistat, a selective, mechanism-based CYP3A inhibitor, was discovered and developed by Gilead Sciences, Inc. In 2013, European Medicines Agency (EMA) approved cobicistat (Tybost) for the treatment of HIV-1 infection in combination with protease inhibitors (PIs) atazanavir or darunavir. Interestingly, cobicistat does not interact with HIV directly, but instead serves as a pharmacokinetic enhancer to boost the anti-HIV effect of atazanavir or darunavir through blockade of CYP3A. Cobicistat slows CYP-mediated metabolism of atazanavir and darunavir, resulting in prolonged systemic exposure of the drug(s). Cobicistat is also available as part of a fixed-dose combination tablet (Stribild) of four additional drugs with CYP3A liabilities (elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate), which was approved in U.S. in 2012, and subsequently approved in Europe and Japan in 2013.용도
Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.Cobicistat 준비 용품 및 원자재
원자재
준비 용품
Cobicistat 공급 업체
글로벌( 189)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou Benoy Chemical Co., Ltd | +8617342059697 |
sales@benoychem.com | China | 315 | 58 |
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 |
sales@alphabiopharm.com | China | 886 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
info@pbpharm.com | CHINA | 498 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |