4-Aminophenylacetic acid
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4-Aminophenylacetic acid 속성
- 녹는점
- 201 °C (dec.) (lit.)
- 끓는 점
- 273.17°C (rough estimate)
- 밀도
- 1.2023 (rough estimate)
- 굴절률
- 1.5635 (rough estimate)
- 인화점
- 201°C
- 저장 조건
- Store below +30°C.
- 산도 계수 (pKa)
- pK1: 3.60;pK2: 5.26 (20°C)
- 물리적 상태
- 가루
- 색상
- 밝은 노란색에서 베이지색까지
- 수용성
- 물에 매우 잘 녹습니다.
- 분해온도
- 201 ºC
- Merck
- 14,463
- BRN
- 2208094
- LogP
- 0.220 (est)
- CAS 데이터베이스
- 1197-55-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-20/21/22 | ||
| 안전지침서 | 22-24/25-36-26 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | AF3550000 | ||
| F 고인화성물질 | 13 | ||
| TSCA | Yes | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29224995 | ||
| 독성 | mouse,LD50,intraperitoneal,3500mg/kg (3500mg/kg),Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958. |
4-Aminophenylacetic acid C화학적 특성, 용도, 생산
화학적 성질
light yellow to beige powder. Soluble in alcohols and alkalis, slightly soluble in hot water.용도
4-Aminophenylacetic acid is used as a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1. It can be detected using HPLC, NMR techniques.제조 방법
p-aminophenylacetic acid is obtained by the reduction of 4-nitrophenylacetic acid. In a reactor, water, 4-nitrophenylacetic acid, and acetic acid are added. The mixture is stirred and heated to 90-95℃. Iron powder is added in portions and refluxed for 2 hours. The mixture is cooled to 40-50℃ and neutralized with sodium carbonate to pH=9, then filtered. The filtrate is further neutralized with acetic acid until pH=4, resulting in the precipitation of 4-aminophenylacetic acid. The yield is 95%.benefits
4-Aminophenylacetonitrile (4-APAN) is an arylacetonitrile and an active substrate for arylacetonitrilase, which gives 4-aminophenylacetic acid (4-APAA) on hydrolysis. 4-APAA is a precursor of 4-acetylaminophenylacetic acid, used in treating rheumatoid arthritis and actarit drugs. 4-APAA also possesses tuberculostatic activity and is helpful as a fibrinolysis inhibitor. In addition to the medical importance of this acid, several derivatives and compounds obtained from 4-APAA showed antimicrobial activity[1].Purification Methods
Crystallise the acid from hot water (60-70mL/g). [Beilstein 14 III 1182.]참고 문헌
[1] BEDAIRAHMED H. Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.[J]. Acta Pharmaceutica, 2006, 56 3: 273-284.[2] MENGYIFAN ZareRichard N GnanamaniElumalai. One-Step Formation of Pharmaceuticals Having a Phenylacetic Acid Core Using Water Microdroplets.[J]. Journal of the American Chemical Society, 2023, 145 14: 7724-7728. DOI:10.1021/jacs.3c00773.
4-Aminophenylacetic acid 준비 용품 및 원자재
원자재
준비 용품
METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE
METHYL 6-QUINOLINEACETATE
4-(DIMETHYLAMINO)PHENYLACETIC ACID
DL-4-HYDROXYPHENYLGLYCINE
(2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-phenylacetic acid
(4-Amino-3-chloro-phenyl)-acetic acid methyl ester
4-히드록시페닐아세트산
ALPHA-AMINOBENZENEACETYL CHLORIDE
1-(CHLOROMETHYL)-3,5-BIS(METHYLSULFONYL)BENZENE
Ethyl 4-aminophenylacetate
4-(1,3-BENZOTHIAZOL-2-YLMETHYL)ANILINE
2-(4-ACETAMIDO-3-NITROPHENYL)ACETIC ACID
(4-Hydrazinophenyl)acetic acid
Methyl 2-(4-aMino-3-iodophenyl)acetate
2-(4-(4-(4-(2-chlorophenylcarbaMoyl)phenylaMino)-5-fluoropyriMidin-2-ylaMino)phenyl)acetic acid
{4-[(CHLOROACETYL)AMINO]PHENYL}ACETIC ACID
4-Aminophenylacetic acid 공급 업체
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