KT5720
|
|
KT5720 속성
- 끓는 점
- 715.0±60.0 °C(Predicted)
- 밀도
- 1.49±0.1 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- 메탄올: 5mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 11.96±0.40(Predicted)
- 색상
- 하얀색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
KT5720 C화학적 특성, 용도, 생산
개요
Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 μM (physiologic ATP). Non-화학적 성질
White solid용도
KT 5720 is a potent, specific and cell-permeable inhibitor of PKA.정의
ChEBI: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3- arboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol- -one.생물학적 활성
Potent, selective inhibitor of protein kinase A (K i = 60 nM). Has no effect on PKG or PKC (K i > 2 μ M). Reversibly arrests human skin fibroblasts in the G 1 phase. Also available as part of the Mixed Kinase Inhibitor Tocriset™ and PKA Tocriset™ .KT5720 준비 용품 및 원자재
원자재
준비 용품
KT5720 공급 업체
글로벌( 113)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 |
shchemsky@sina.com | China | 15421 | 60 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 |
China | 9900 | 58 | |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 |
marketing@targetmol.com | China | 7854 | 58 |
KT5720 관련 검색:
Adenosine 3',5'-cyclic monophosphate sodium salt
8-CHLORO-CAMP
PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED
8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
9-ISOPROPYLCARBAZOLE
1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97
KT5720
N-Ethyl-3-carbazolecarboxaldehyde
9-CARBAZOLEPROPIONIC ACID
K-252C
K-252B
11,12-Dihydroindolo[2,3-a]carbazole
1-ethyl-1H-indole-4-carbaldehyde
CARBAZOL-9-YL-METHANOL
KT-5720
KT5720 in Solution
KT5720 (Selective PKA Inhibitor)
KT5720 (semi-synthetic derivative of K525a), Selective PKA Inhibitor, 0.5376kD