피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P304+P340
흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P310
즉시 의료기관(의사)의 진찰을 받으시오.
삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P363
다시 사용전 오염된 의류는 세척하시오.
P370+P378
화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P403+P235
환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
1-브로모디벤조티오펜 C화학적 특성, 용도, 생산
용도
1-Bromodibenzothiophene can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthesis
Into a 1 L four-necked round bottom flask equipped with a stirrer, a Liebig condenser (not required), a 100 mL dropping funnel and a thermometer, 43.5 g (0.156 mol) of the amine hydrochloride obtained in the above ), 240 mL of acetic acid, 55 mL of concentrated hydrochloric acid and 143 mL of water were placed and cooled to -5 ?? C. or lower in an ice water bath. Next, an aqueous solution of 12.0 g (0.173 mol) of sodium nitrite dissolved in 67 mL of water was added dropwise from the dropping funnel at a temperature not exceeding 5 ?? C., and the mixture was stirred at 5 ?? C. or less for 1 hour.The resulting diazo solution was transferred to a 1 L dropping funnel and set in a 1 L 4-necked round bottom flask equipped with a stirrer, a Liebig condenser (not required) and a thermometer, and then 50 % Hypophosphorous acid and 90 mL of water were added, and the mixture was cooled to -5 ?? C. or lower in an ice water bath. Subsequently, the diazo solution was added dropwise at a temperature not exceeding 5 ?? C., after stirring for 1 hour in an ice water bath, it was returned to room temperature and stirred at room temperature for 48 hours.The obtained reaction solution was extracted twice with 310 mL of ethyl acetate, then washed twice with 310 mL of water, dried with magnesium sulfate, magnesium sulfate was removed by suction filtration, and the solvent was distilled off under reduced pressure. Subsequently, the obtained crude oil was purified on a silica gel column using n-heptane as a developing solution to obtain 33.8 g (yield: 82.5%) of the desired bromide.
