루굴로신

루굴로신
루굴로신 구조식 이미지
카스 번호:
23537-16-8
한글명:
루굴로신
상품명:
RUGULOSIN
동의어(영문):
RUGULOSIN;Nsc160880;NSC 249990;Rugulosin A;(+)-Rugulosin;(+)-RUGULOSIN;(+)-(1S,1'S,2R,2'R,3S,3'S,9AR,9'AR)-RUGULOSIN;(+)-Rugulosin, (1S,1S,2R,2R,3S,3S,9aR,9aR)-Rugulosin, (2R,2R)-Rugulosin;5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-;5H,6H-6,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-, (5aS,6R,13aS,14R,17S,18R,19R,20S)-
CBNumber:
CB7701377
분자식:
C30H22O10
포뮬러 무게:
542.49
MOL 파일:
23537-16-8.mol

루굴로신 속성

녹는점
293℃ (decomposition)
끓는 점
535.95°C (rough estimate)
밀도
1.3164 (rough estimate)
굴절률
1.5376 (estimate)
저장 조건
Store at -20°C
용해도
DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
물리적 상태
고체
산도 계수 (pKa)
4.20±1.00(Predicted)
IARC
3 (Vol. 40, Sup 7) 1987
EPA
5H,6H-6,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-, (5aS,6R,13aS,14R,17S,18R,19R,20S)- (23537-16-8)

안전

HS 번호 29419000

루굴로신 C화학적 특성, 용도, 생산

개요

(+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 μM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 μM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 μM. (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet. It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 μg/ml, respectively).

용도

(+)-Rugulosin is an intense yellow pigment produced by some species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. (+)-Rugulosin shows antibacterial and insecticidal activity and has found application as a bioinsecticide, notably as the active secondary metabolite in endophytic fungi of seedlings.

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