트랜스클로미펜HCL

트랜스클로미펜HCL
트랜스클로미펜HCL 구조식 이미지
카스 번호:
15690-57-0
한글명:
트랜스클로미펜HCL
동의어(한글):
트랜스클로미펜HCL
상품명:
Enclomiphene
동의어(영문):
enclomiphene;Enclomifene;EncloMiphene-d4;trans-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethylethanamine;ici46476;RMI 16,289;(E)-Clomiphene;trans-clomifene;E-CloMiphene-d4;trans-clomiphene
CBNumber:
CB8128416
분자식:
C26H28ClNO
포뮬러 무게:
405.96
MOL 파일:
15690-57-0.mol

트랜스클로미펜HCL 속성

녹는점
149.0-150.5°
끓는 점
509.0±50.0 °C(Predicted)
밀도
1.104±0.06 g/cm3(Predicted)
산도 계수 (pKa)
9.60±0.25(Predicted)

안전

트랜스클로미펜HCL C화학적 특성, 용도, 생산

개요

Enclomiphene is a synthetic and nonsteroidal antiestrogen. It is the more potent isomer and the one responsible for its ovulation-inducing actions. The half-life of enclomiphene is relatively short, so serum concentrations rise and fall quickly during and after treatment. Antiestrogens represent the first-line treatment strategy in WHO class-2 anovulatory infertility.

용도

trans-Clomiphene is a Clomiphene (C587025) stereoisomer, a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility.

제조 방법

CONDENSATION OF 4-HYDROXYBENZOPHENONE WITH 2-(DIETHYLAMINO)ETHYL CHLORIDE FOLLOWED BY TREATMENT WITH BENZYL MAGNESIUM CHLORIDE AND DEHYDRATION TO GIVE 2-(P-(1,2-DIPHENYLVINYL)PHENOXY)TRIETHYLAMINE WHICH IS CHLORINATED AND TREATED WITH CITRIC ACID /CITRATE/

생물학적 활성

Enclomiphene is the trans-isomer of clomiphene citrate (CC). It has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene. Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer.

Mode of action

Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. The main mechanism of its action is thought to be its antagonistic effects on the hypothalamic-pituitary axis and stimulation of GnRH secretion.

트랜스클로미펜HCL 준비 용품 및 원자재

원자재

준비 용품


트랜스클로미펜HCL 공급 업체

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