Andarine

Andarine 속성

Andarine C화학적 특성, 용도, 생산

개요

Andarine, also known as S4 or S-4, is a selective androgen receptor modulator that was developed to treat muscle wasting diseases, and cancer patients who were wasting away. S-4 is an anabolic agonist that is effective and does not have the same side effects as anabolic-androgenic steroids. Its effectiveness is primarily due to its substrate affinity for 5α-reductase, which produces DHT in the prostate. Unfortunately the benefits that SARMs such as andarine (S-4) may provide to clinical medicine have the potential for misuse in sports where athletes and/or their handlers may seek to gain unfair advantage with the assumption that these compounds are undetectable by anti-doping laboratories. SARMs are therefore prohibited for use by the International Federation of Horseracing Authorities and the World Anti-Doping Agency (WADA).

화학적 성질

Pale Yellow Solid

용도

Andarine is a potent and tissue-selective androgen receptor modulator (SARM) that is commonly used for lean gains, muscle hardening, and fat loss. Unlike other normies, it delivers impressive results without posing any serious risks to health.

정의

ChEBI: Andarine is an anilide and a member of acetamides. It is a non-steroidal selective androgen receptor modulator.

benefits

Andarine (S4) has a lot of great benefits and this is probably what you are most interested in.
The Andarine benefits are:
Increased muscle mass
Fat loss
Faster recovery
Body recomposition
Increased strength

부작용

Andarine has gone through quite a bit of research but not as much as other SARMs such as LGD 4033 or Ostarine. From the studies so far and from the anecdotal evidence from people that use it we can tell that there are two side effects.
S4 side effects:
Suppression
Impaired vision

Synthesis

Andarine was prepared from N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide  (0.37 g, 1.0 mmol), 4-acetamidophenol (0.23 g, 1.5 mmol) K2CO3 (0.28 g, 2.0 mmol), and 10% of benzyltributylammonium chloride as a phase transfer catalyst in 20 mL of methyl ethyl ketone was heated at reflux overnight under argon. The reaction was followed by TLC, the resulting mixture was filtered through Celite, and concentrated in vacuo to dryness. Purification by flash column chromatography on silica gel (hexanes-ethyl acetate, 3:1) yielded 0.38 g (86%) (Rf=0.18 hexanes-ethyl acetate, 3:1) of the desired compound as a light yellow powder: mp 70-74° C.

Clinical claims and research

The pharmacological activity of andarine suggest the great potential of andarine in the development of the clinically available SARMs, which offers unique therapeutic advantages over their steroidal counterparts and an exciting opportunity to differentially regulate the androgen effects in various target tissues, thus minimizing the interference to normal. Thus, andarine has promising in advanced clinical trials that aim to treat age-related maladies and to counteract symptoms of severe diseases such as sarcopenia and cancer cachexia.
However, andarine may be misused in sports where athletes and/or their handlers may seek to gain unfair advantage. Therefore, andarine as agonist is prohibited for use by the International Federation of Horseracing Authorities and the World Anti-Doping Agency.

Regulatory Status

Andarine also named SARM S-4, classified in the S1 class of the WADA prohibited list.
US: Andarine is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website.
United Nations: The substance is not listed specifically on the Yellow List - List of Narcotic Drugs under International Control nor the Green List - List of Psychotropic Substances under International Control.
Canadian Status: Andarine is not currently listed in the CDSA. The substance has been reported to be used for the treatment of muscle wasting, osteoporosis and begning prostatic hyperplaysia and displays androgenic and anabolic activity1-3 . 2 3However, since andarine is not a steroid, it cannot be included uner item 23 of Schedule IV to the CDSA.

Andarine 준비 용품 및 원자재

원자재

준비 용품

Andarine 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Wuhan Aoliqisi New Material Technology Co., Ltd.	+86-13545906766; +8613545906766	sales@whaop.com	China	265	58
qingdao future trading Co., Ltd	+86-13335044410 +86-13335044410	cui56813@163.com	China	110	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	274	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
Dorne Chemical Technology co. LTD	+86-13583358881 +86-18560316533	Ethan@dornechem.com	China	300	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	436	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	305	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	248	58

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