Rivastigmine
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Rivastigmine 속성
- 알파
- D20 -32.1° (c = 5 in ethanol)
- 끓는 점
- 316.2±34.0 °C(Predicted)
- 밀도
- 1.038±0.06 g/cm3(Predicted)
- 인화점
- 145℃
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- 클로로포름(적게), 에틸아세테이트(약간)에 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- pKa 8.99 (Uncertain)
- CAS 데이터베이스
- 123441-03-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 유엔번호(UN No.) | UN 2810 6.1 / PGIII | ||
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| HS 번호 | 2924296000 |
| 그림문자(GHS): |
 
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Rivastigmine C화학적 특성, 용도, 생산
용도
Antidepressant정의
ChEBI: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.일반 설명
Rivastigmine (Exelon, EA 713) is apseudoirreversible noncompetitive carbamate inhibitor ofAChE. Although the half-life is approximately 2 hours,the inhibitory properties of this agent last for 10 hours becauseof the slow dissociation of the drug from the enzyme.The Food and Drug Administration (FDA) approved its usein mild-to-moderate Alzheimer disease in April 2000. InJuly 2007, rivastigmine was granted approval for use inmanaging mild-to-moderate dementia associated withParkinson disease.Pharmacokinetics
Rivastigmine is a centrally selective, arylcarbamate AChEI that was approved in 2000 for oral administration in the treatment of AD. It has an elimination half-life of 1.4 to 1.7 hours but is able to inhibit AChE for up to 10 hours. Because of the slow dissociation of the carbamylated enzyme, it has been referred to as a pseudo-irreversible AChEI. Like donepezil, rivastigmine exhibits a low level of hepatotoxicity. It is rapidly and extensively hydrolyzed in the CNS by cholinesterase with minimal involvement of CYP450. The phenolic metabolite is excreted primarily via the kidneys.신진 대사
Rivastigmine is the tertiary amines that are rapidly absorbed from the gastrointestinal tract, as are tacrine, donepezil, and galanthamine, whereas quaternary ammonium compounds are poorly absorbed after oral administration. Nevertheless, quaternary ammonium compounds like neostigmine and pyridostigmine are orally active if larger doses are employed. Only the quaternary ammonium inhibitors do not readily enter the CNS. Because of their high lipid solubility and low molecular weight, most of the organophosphates are absorbed by all routes of administration; even percutaneous exposure can result in the absorption of sufficient drug to permit the accumulation of toxic levels of these compounds.Rivastigmine 준비 용품 및 원자재
원자재
(S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide
Rivastigmine hydrochloride
Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-aminoethyl]phenyl ester
1257519-35-9
Methanamine, N-(benzoyloxy)-N-methyl-
3-(1-(디메틸아미노)에틸]페놀
3-[(1S)-1-(디메틸아미노에틸)]페놀
에틸메틸-카르밤산염화물
리바스티그민EP불순물E
3-(1-hydroxyethyl)phenyl ethyl(methyl)carbamate
(R)-3-(1-hydroxyethyl)phenylethyl(methyl)carbamate
준비 용품
Rivastigmine 공급 업체
글로벌( 307)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 |
guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12470 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8829 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |