키스펩틴-10
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키스펩틴-10 속성
- 밀도
- 1.46±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 9.96±0.15(Predicted)
- 수용성
- 1mg/ml로 물에 용해됨
- 시퀀스
- H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- InChIKey
- RITKWYDZSSQNJI-INXYWQKQSA-N
안전
WGK 독일 | 3 |
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키스펩틴-10 C화학적 특성, 용도, 생산
개요
Kisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.용도
Kisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.Biological Functions
Metastin serves as a tumor suppressor by hindering the growth of secondary tumors. When KISS1R (KISS1 receptor) is activated upon binding with KISS1, it boosts intracellular calcium levels and activates MAPKs, which in turn limit cell mobility and proliferation. Metastin is a potential therapeutic target for various cancers, including melanoma, thyroid, bladder, squamous cell carcinoma of the esophagus, gastric, hepatocellular, and breast cancers.In addition to its role in cancer suppression, metastin plays a critical role in reproduction. It regulates the hypothalamic-pituitary-gonadal axis by modulating gonadotropin-releasing hormone (GnRH) secretion, which influences the onset of puberty. Gene mutations can lead to central precocious puberty (CPP) in males, while impaired metastin signaling can result in isolated hypogonadotropic hypogonadism (IHH) in both humans and mice. Metastin can also elevate plasma levels of gonadotropins (follicle-stimulating hormone and luteinizing hormone) and promote ovulation in prepubescent female rats.
일반 설명
Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novel?peptide?is mainly isolated from the human placenta.Biochem/physiol Actions
Kisspeptin 10 (human) is a highly effective natural ligand for the Kisspeptin receptor (KISS1, GPR54). It exhibits strong binding affinity to rat and human KISS1 receptors, with Ki values of 1.59 and 2.33 nM respectively. This peptide inhibits metastasis and invasion in mouse melanomas and triggers gonadotropin release upon intracerebroventricular administration.Clinical claims and research
Kisspeptin-10 level is useful in assessing the severity of preeclampsia and can be a novel marker downregulated in pregnant women with preeclampsia, especially in those who also developed impaired uteroplacental perfusion or intrauterine growth restriction[2].키스펩틴-10 준비 용품 및 원자재
원자재
준비 용품
키스펩틴-10 공급 업체
글로벌( 172)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Qingdao Xinli Technology Development Co., Ltd. | +8616632313095 |
xinlikeji01@qdxlchem.com | China | 60 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 971 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 |
mike@ge-tian.com | China | 274 | 58 |
CONTIDE BIOTECH CO.,LTD | +852-53358525 |
xena@healthtide-api.com | China | 619 | 58 |
Apeloa production Co.,Limited | +8619933239880 |
admin@apcl.com.cn | China | 341 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 |
ably@aljbio.com | China | 196 | 58 |
Strong peptide cross-border e-commerce Co. LTD | +undefined13930052870 |
qt01@qiangtaipharm.com | China | 81 | 58 |
Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 |
sales2@qschem-pharma.com | China | 46 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 |
asdf@shanghaihg.cn | China | 265 | 58 |
키스펩틴-10 관련 검색:
H-SER-ILE-LYS-VAL-ALA-VAL-OH
Hexapeptide 9
cilengitide
PalMitoyl Tripeptide-1
Glutathione
Cibinetide
Irofulven
glucagon-like peptide 1
Palmitoyl Hexapeptide-12
Acetyl Dipeptide-1 cetyl ester
IRL-1620
Hexapeptide-11
DERMASEPTIN PHYLLOMEDUSA SAUVAGII
CYCLOXYDIM
H-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
Kisspeptin 10 (human)
H-KDLPNYNWNSFGLRF-NH2
[125I]METASTIN (45-54) AMIDE, HUMAN