ChemicalBook >제품 카탈로그 >API>신경계 약물>항 정신병 제>둘록세틴

둘록세틴

둘록세틴 구조식 이미지

카스 번호:: 116539-59-4

한글명:: 둘록세틴

동의어(한글):: 둘록세틴

상품명:: Duloxetine

동의어(영문):: DULOXETIN;DULOXETINE HCI;DULOXETINE-D3;(S)-DULOXETINE;(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine;CS-559;DULOXETINE;(+)-Duloxetine;Duloxetine, >=99%;Duloxetine Hcl(S)

CBNumber:: CB8670379

분자식:: C18H19NOS

포뮬러 무게:: 297.41

MOL 파일:: 116539-59-4.mol

속성

안전

용도

공급 업체 197

둘록세틴 속성

끓는 점: 466.2±40.0 °C(Predicted)

밀도: 1.158±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

산도 계수 (pKa): 10.02±0.10(Predicted)

BCS Class: 2

InChI: InChI=1/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/s3

InChIKey: BFFSMCNJSOPUAY-VOPAOICTNA-N

SMILES: C1(=CC=CS1)[C@H](CCNC)OC1=CC=CC2=CC=CC=C12.Cl |&1:5,r|

EPA: 2-Thiophenepropanamine, N-methyl-?-(1-naphthalenyloxy)-, (?S)- (116539-59-4)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

유해 물질 데이터	116539-59-4(Hazardous Substances Data)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

둘록세틴 C화학적 특성, 용도, 생산

용도

Antidepressant.

일반 설명

Duloxetine (Cymbalta) is a newer antidepressant. It islargely like venlafaxine, which is an SNERI (selective norepinephrinereuptake inhibitor).

Pharmacokinetics

Duloxetine appears to be fairly well absorbed after oral doses, with peak plasma levels in 6 to 10 hours and linear pharmacokinetics. The drug is extensively metabolized in the liver to active metabolites, with 72% of an oral dose primarily excreted in the urine as conjugated metabolites and up to 15% appearing in the feces.
N-demethylation to an active metabolite (CYP2D6) and hydroxylation of the naphthyl ring (CYP1A2) at either the 4-, 5-, or 6-positions are the main metabolic pathways for duloxetine. Its metabolites are primarily excreted into the urine as glucuronide, sulfate, and O-methylated conjugation products. The major metabolites found in plasma also were found in the urine. Preclinical data for 4-hydroxyduloxetine suggests it has a similar pharmacological profile to duloxetine, with selective inhibition of SERT but less activity at the NET.

Clinical Use

Duloxetine has been approved for the treatment of depression and diabetic peripheral neuropathic pain. It is another analogue in the line of fluoxetine-based products from Lilly, in which the phenyl and phenoxy groups of fluoxetine have been respectively replaced with the benzene isostere, thiophene, and a naphthyloxy group (previously described under fluoxetine). Duloxetine exhibits dual inhibition with high affinity for the SERTs and NETs, with a five times preferential inhibition of the SERT. Duloxetine appears to be a more potent in vitro blocker of SERTs and NETs than venlafaxine. In humans, duloxetine has a low affinity for the other neuroreceptors, suggesting low incidence of unwanted adverse effects.

둘록세틴 준비 용품 및 원자재

원자재

1-Fluoronaphthalene

준비 용품

둘록세틴 공급 업체

글로벌( 197)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12468	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
WinWin Chemical CO., Limited	+86-0577-64498589 +8615325081899	sales@win-winchemical.com	China	14145	58

둘록세틴 관련 검색:

파록세틴 Duloxetine intermediate Duloxetine intermediate AA Duloxetine hydrochoride (rs)-duloxetine hydrochloride,(rs)-n-methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride (r)-duloxetine,R-DULOXETINE HCL,(r)-n-methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine Duloxetine Duloxetine hydrochloride 4-Hydroxy Duloxetine 4-Hydroxy Duloxetine -D-Glucuronide,4-Hydroxy Duloxetine b-D-Glucuronide S-(+)-N,N-DIMETHYL-3-(1-NAPHTHLENYLOXY)-3-(2-THIENYL)-PROPANAMINE Duloxetine-d3 HCl R-DULOXETINE HYDROCHLORIDE Duloxetine-naphthyl-D7 Maleate DULOXETINE MALEATE 5-Hydroxy-6-methoxy Duloxetine 5-Hydroxy-6-methoxy duloxetine sulfate