Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.
화학적 성질
White to off-white lyophilized powder
용도
Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome
주요 응용
Hygromycin B was found in the culture broth of Streptomyces hygroscopicus by Lilly Research Laboratories in 1953, as a mixture with hygromycin A. It showed activity against a variety of gram-positive and gram-negative bacteria as well as fungi. Hygromycin B has been used for therapy of helminthic infections in swine and poultry.
일반 설명
Amorphous solid or tan powder.
공기와 물의 반응
Water soluble.
반응 프로필
Weakly basic.
화재위험
Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.
Safety Profile
Poison by
intraperitoneal route. Mutation data
reported. When heated to decomposition it
emits toxic fumes of Nox