L-발리놀
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L-발리놀 속성
- 녹는점
- 30-34 °C
- 끓는 점
- 81 °C8 mm Hg(lit.)
- 알파
- 16 º (c=10,EtOH)
- 밀도
- 0.926 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.4548(lit.)
- 인화점
- 196 °F
- 저장 조건
- Store at +2°C to +8°C.
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 12.82±0.10(Predicted)
- 물리적 상태
- 녹은 후에 액체
- 색상
- 약간 노란색으로 맑음
- optical activity
- [α]25/D +10°, c = 10 in H2O
- 수용성
- 물에 용해됩니다.
- 감도
- Air Sensitive
- BRN
- 1719137
- InChIKey
- NWYYWIJOWOLJNR-RXMQYKEDSA-N
- CAS 데이터베이스
- 2026-48-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36-36/37/38 | ||
| 안전지침서 | 26-24/25-36 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 10-23 | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29221980 |
L-발리놀 C화학적 특성, 용도, 생산
화학적 성질
white to light yellow crystal powde용도
L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.Purification Methods
Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]L-발리놀 준비 용품 및 원자재
원자재
준비 용품
(4S 4'S)-(-)-2 2'-(3-PENTYLIDENE)BIS(4-&
(S)-4,5-DIHYDRO-2-(2-((S)-4,5-DIHYDRO-4-ISOPROPYLOXAZOL-2-YL)PROPAN-2-YL)-4-ISOPROPYLOXAZOLE
(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone
(S,S)-2,6-BIS(4-ISOPROPYL-2-OXAZOLIN-2-YL)PYRIDINE
1-[(4S)-4-(1-Methylethyl)-2-thioxo-3-oxazolidinyl]-
Carbamic acid, [(1R)-1,2-dimethylpropyl]-, 1,1-dimethylethyl ester (9CI)
5-isopropylmorpholin-3-one
CYCLO(-VAL-VAL)
(S)-4-(1-Isopropyl)-3-(1-oxobutyl)-2-oxazolidinone
(S)-1-Methoxymethyl-2-methyl-propylamine
L-발리놀 공급 업체
글로벌( 500)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8615680023009 |
daisy@enlaibio.com | China | 1369 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 16805 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15932 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9346 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 |
christine@shengqipharm.com | CHINA | 491 | 58 |