다이에틸설페이트
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다이에틸설페이트 속성
- 녹는점
- -24 °C (lit.)
- 끓는 점
- 208 °C (lit.)
- 밀도
- 1.177 g/mL at 25 °C (lit.)
- 증기 밀도
- 5.3 (vs air)
- 증기압
- <0.01 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.399(lit.)
- 인화점
- 173 °F
- 저장 조건
- Refrigerator (+4°C)
- 용해도
- soluble in Ether,Alcohol
- 물리적 상태
- 액체
- 색상
- 투명한
- 냄새
- 숯. 희미한 에테르 냄새, 자극적인 후유증
- 수용성
- 5g/L(20℃)
- Merck
- 14,3130
- BRN
- 1209714
- Dielectric constant
- 29.0(20℃)
- 안정성
- 수분에 민감합니다. 산화제와 격렬하게 반응할 수 있음.
- CAS 데이터베이스
- 64-67-5(CAS DataBase Reference)
- IARC
- 2A (Vol. 54, 71) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 45-46-20/21/22-34 | ||
안전지침서 | 53-45 | ||
유엔번호(UN No.) | UN 1594 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | WS7875000 | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29209090 | ||
유해 물질 데이터 | 64-67-5(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 0.88 g/kg (Smyth) | ||
기존화학 물질 | KE-32592 | ||
유해화학물질 필터링 | 97-1-407 | ||
중점관리물질 필터링 | 별표1-8 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 황산 디에틸 및 이를 0.1% 이상 함유한 혼합물 |
다이에틸설페이트 C화학적 특성, 용도, 생산
화학적 성질
Diethyl sulfate is a colorless, oily liquid with a faint peppermint- like odor, which darkens with age (Budavari, 1996). It is miscible with alcohol and ether (O'Neil, 2006). At higher temperatures, DES rapidly decomposes into monoethyl sulfate and alcohol (NTP, 2011).용도
The primary use of diethyl sulfate is as a chemical intermediate (ethylating agent) in synthesis of ethyl derivatives of phenols, amines, and thiols; as an accelerator in the sulfation of ethylene; and in some sulfonation processes. It is used to manufacture dyes, pigments, carbonless paper, and textiles. It is an intermediate in the indirect hydration (strong acid) process for the preparation of synthetic ethanol from ethylene. Smaller quantities are used in household products, cosmetics, agricultural chemicals, pharmaceuticals, and laboratory reagents (IARC 1992, 1999, HSDB 2009). In 1966, it was used as a mutagen to create the Luther variety of barley (IARC 1974).주요 응용
Diethyl sulfate can be used as a reactant for the synthesis of:Biologically active compounds such as bispyrazole, pyrazolopyrimidine and pyridine containing antipyrinyl moieties.
N-substituted-2-styryl-4(3H)-quinazolinones.
Ionic liquids with pyrrolidinium, piperidinium and morpholinium cations, having potential applications as electrolytes.
It can also be used as an alkylating agent to synthesize 1-alkyl/aralkyl-2-(1-arylsufonylalkyl)benzimidazoles and an ionic liquid ethylmethylimidazole ethylsulfate ([EMIM][EtSO4].
제조 방법
Diethyl sulfate is produced from ethanol and sulfuric acid, from ethylene and sulfuric acid, or from diethyl ether and fuming sulfuric acid (Budavari, 1996).정의
ChEBI: Diethyl sulfate is the diethyl ester of sulfuric acid. It has a role as a carcinogenic agent, an apoptosis inducer, an alkylating agent and a mutagen.일반 설명
Diethyl sulfate appears as a clear colorless liquid with a peppermint odor. Burns, though may be difficult to ignite. Corrosive to metals and tissue. It is a potent alkylating agent.공기와 물의 반응
Highly flammable. Slowly reacts with water to form ethyl alcohol, a flammable liquid, and ethyl sulfate, with eventual conversion to sulfuric acid.반응 프로필
The presence of moisture in a metal container of Diethyl sulfate caused the formation of sulfuric acid which reacts with the metal to release hydrogen which pressurized and exploded the container [Chem. Abst. 28:2908(1934)].건강위험
May be fatal if inhaled, swallowed or absorbed through skin. Inhalation causes nausea and vomiting. Causes burns to skin and eyes. Ingestion may cause nausea, vomiting abdominal pain and collapse.Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by inhalation and subcutaneous routes. Moderately toxic by ingestion and sktn contact. A severe skin irritant. An experimental teratogen. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. Moisture causes liberation of H2SO4. Violent reaction with potassium tert-butoxide. Reacts violently with 3,8-dnitro-6-phenylphenanthridine + water. Reaction with iron + water forms explosive hydrogen gas. To fight fire, use alcohol foam, H2O foam, CO2, dry chemicals. When heated to decomposition it emits toxic fumes of SOx. See also SULFATES.Carcinogenicity
Diethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.Purification Methods
Wash the ester with aqueous 3% Na2CO3 (to remove acidic material), then distilled water, dry (CaCl2), filter and distil it in a vacuum. It is an ethylating agent and blisters the skin. [Beilstein 1 IV 1236.]다이에틸설페이트 준비 용품 및 원자재
원자재
준비 용품
Ethoxyamine hydrochloride
N,N-DIETHYL-O-TOLUIDINE
softener qA
4-aminopyrimidin-2-ol
3-Ethoxyphenol
Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate
N4-Benzoylcytosine
S-에틸 디프로필티오카바민산
4-아미노-5-카르복시-2-에틸-메르캅토피리미딘
몰리네이트
ETHYL 4-ETHOXYPHENYLACETATE
에틸디글리콜
4-클로로페네톨
Trepibutone
9-에틸카바졸
4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE
크로타미톤
디에틸에테르
산성오렌지116
2-에톡시벤조산
베타-나프틸에틸에테르
Ethyl 2-ethylacetoacetate
다이에틸설페이트 공급 업체
글로벌( 364)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12470 | 58 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32715 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8829 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |