NOVOBIOCIN SODIUM SALT
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NOVOBIOCIN SODIUM SALT 속성
- 녹는점
- 215-220 C
- 알파
- D24 -38° (c = 2.5 in 95% ethanol); D24 -33° (c = 2.5 in water)
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- H2O: 용해성50mg/mL
- 물리적 상태
- 흰색에서 노란색 고체
- 색상
- 흰색에서 희미한 베이지색
- 수소이온지수(pH)
- 7.5 (100g/l, H2O, 25℃)
- optical activity
- [α]20/D 48±3°, c = 1% in ethanol
- 수용성
- 100mg/ml로 물에 용해됩니다. 또한 에탄올에 용해되거나 DMSO물, 에탄올, 디메틸둘폭시드 및 메탄올에 용해됩니다.
- Merck
- 13,6755
- BRN
- 3892910
- 안정성
- 흡습성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 43-36-36/37/38-20/21/22 | ||
| 안전지침서 | 36-36/37-26-37/39 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | RD5425000 | ||
| F 고인화성물질 | 8-10 | ||
| HS 번호 | 2941 90 00 | ||
| 독성 | LD50 orally in Rabbit: 3500 mg/kg |
NOVOBIOCIN SODIUM SALT C화학적 특성, 용도, 생산
화학적 성질
crystalline용도
Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.Novobiocin sodium salt is twice as bioavailable as the calcium salt and 50 times more available than the parent acid.
Clinical Use
The action of novobiocin is largely bacteriostatic. Itsmode of action is not known with certainty, though it doesinhibit bacterial protein and nucleic acid synthesis. Studiesindicate that novobiocin and related coumarin-containingantibiotics bind to the subunit of DNA gyrase and possiblyinterfere with DNA supercoiling and energy transductionin bacteria. The effectiveness of novobiocin is confinedlargely to Gram-positive bacteria and a few strains of P. vulgaris.Its low activity against Gram-negative bacteria is apparentlybecause of poor cellular penetration.Although cross-resistance to other antibiotics is reportednot to develop with novobiocin, resistant S. aureus strainsare known. Consequently, the medical use of novobiocin isreserved for the treatment of staphylococcal infections resistantto other antibiotics and sulfas and for patients allergicto these drugs. Another shortcoming that limits the usefulnessof novobiocin is the relatively high frequency ofadverse reactions, such as urticaria, allergic rashes, hepatotoxicity,and blood dyscrasias.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.Purification Methods
The sodium salt has been recrystallised from MeOH, then dried at 60o/0.5mm. [Sensi et al, Anal Chem 29 1611 1957, Kaczka et al. J Am Chem Soc 78 4126 1956, Beilstein 18/8 IV 8125.]NOVOBIOCIN SODIUM SALT 준비 용품 및 원자재
원자재
준비 용품
NOVOBIOCIN SODIUM SALT 공급 업체
글로벌( 196)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| TopScience Biochemical | 00852-68527855 |
info@itopbiochem.com | China Hong Kong | 902 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9126 | 58 |
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