17-AAG manufacturers and suppliers

17-AAG suppliers

Properties

Melting point:: 201-203°C

Boiling point:: 797.8±60.0 °C(Predicted)

Density: 1.21

RTECS: LX8932000

Flash point:: >110°(230°F)

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility: DMSO: soluble

form: solid

pka: 8.62±0.70(Predicted)

color: Purple or dark red

Water Solubility: Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water

Sensitive: Light Sensitive

Stability:: Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H317

Precautionary statements: P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 22-24/25-36-26

WGK Germany: 3

HS Code: 29419090

Use

Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

You can find 17-AAG suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.