3-CHLORO-5-HYDROXY-BENZOIC ACID manufacturers and suppliers

3-CHLORO-5-HYDROXY-BENZOIC ACID suppliers

3-CHLORO-5-HYDROXY-BENZOIC ACID

CAS:: 53984-36-4

MF:: C7H5ClO3

MW:: 172.57

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Properties

Melting point:: 244.0 to 248.0 °C

Boiling point:: 364.8±27.0 °C(Predicted)

Density: 1.536±0.06 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

solubility: DMSO: soluble15mg/mL (clear solution)

form: powder

pka: 3.71±0.10(Predicted)

color: white to beige

InChIKey: RJOLIYHZZKAIET-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS05,GHS07

Signal word: Danger

Hazard statements: H302-H315-H318-H335

Precautionary statements: P261-P280-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-37/38-41

Safety Statements: 26-36

WGK Germany: 3

HS Code: 2916399090

Use

GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[Cayman Chemical]

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