Tylosin manufacturers and suppliers

Tylosin suppliers

Properties

Melting point:: 135-137°C

alpha: D25 -46° (c = 2 in methanol)

Boiling point:: 796.05°C (rough estimate)

Density: 1.1424 (rough estimate)

refractive index: 1.5280 (estimate)

storage temp.: Sealed in dry,2-8°C

solubility: DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml

form: A crystalline solid

pka: pKa 7.73(H2O t = 25 I = 0.167) (Uncertain)

Water Solubility: H2O: soluble 50 mg/mL

Stability:: Solutions are stable at pH 4-9 (most stable at pH 7);
Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis;
In neutral and alkaline pH – tylosin aldol (TAD) is formed together with polar degradation products of unknown identity;
When tylosin solution is exposed to daylight, a photodegradation product - isotylosin A (isoTA) is formed.

InChIKey: WBPYTXDJUQJLPQ-VMXQISHHSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H317-H334

Precautionary statements: P261-P272-P280-P284-P302+P352-P333+P313

Hazard Codes: Xn,N

Risk Statements: 42/43-50

Safety Statements: 36-61-45-36/37-22

HS Code: 2941906000

Toxicity: Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.

Use

Tylosin is a 16-membered macrocyclic lactone isolated from Streptomyces fradiae in 1961. Tylosin has broad spectrum antibacterial activity and was developed as a veterinary pharmaceutical for treatment of bacterial infections in a range of domestic animals . Tylosin acts by binding to the 50S ribosomal subunit resulting in the inhibition of protein synthesis in bacteria.

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