AZD-8055 manufacturers and suppliers

AZD-8055 suppliers

Properties

Melting point:: 204 - 207°C

Boiling point:: 694.3±65.0 °C(Predicted)

Density: 1.248

storage temp.: -20°C

solubility: Soluble in DMSO (up to 30 mg/ml)

form: Yellow powder.

pka: 14.20±0.10(Predicted)

color: Yellow

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H335-H319-H315

Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Safety Statements: 24/25

HS Code: 29335990

Use

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

You can find AZD-8055 suppliers, manufacturers, and distributors from countries such as China, United States and the The Netherlands here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.