PROCYCLIDINE HYDROCHLORIDE manufacturers and suppliers

PROCYCLIDINE HYDROCHLORIDE suppliers

Properties

Melting point:: 159-164 °C

storage temp.: 2-8°C

solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)

form: Solid

color: White to Off-White

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319

Precautionary statements: P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c

Hazard Codes: Xn

Risk Statements: 20/21/22

Safety Statements: 36

WGK Germany: 3

RTECS: UY1926000

HS Code: 2933997500

Toxicity: mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955.

Use

Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.

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