THIOSTREPTON manufacturers and suppliers

THIOSTREPTON suppliers

Properties

Melting point:: 248-257°C (dec.)

alpha: D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)

Density: 1.0824 (rough estimate)

refractive index: 1.6700 (estimate)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Soluble in DMSO or chloroform

form: Off-white powder

pka: 10.43±0.46(Predicted)

color: Off-white

Water Solubility: 0.24g/L(28 ºC)

Merck: 13,9440

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302+H312+H332

Precautionary statements: P271-P261-P280

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 22-24/25

WGK Germany: 3

RTECS: XN6300100

F: 10-21

HS Code: 29419090

Toxicity: LD50 oral in mouse: > 1gm/kg

Use

Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, and TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

You can find THIOSTREPTON suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.