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ChemicalBook >> CAS DataBase List >> 9-Aminocamptothecin

9-Aminocamptothecin

9-Aminocamptothecin price.
  • $25 - $2350
  • Product name: 9-Aminocamptothecin
  • CAS: 91421-43-1
  • MF: C20H17N3O4
  • MW: 363.37
  • EINECS:
  • MDL Number:MFCD00909855
  • Synonyms:4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione;4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-;CAMPTOTHECIN, 9-AMINO-(RG);(S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di;CAMPTOTHECIN, 9-AMINO-;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN
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  • 1g
  • ManufacturerAK Scientific
  • Product numberK664
  • Product description9-Aminocamptothecin
  • Packaging10mg
  • Price$97
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberK664
  • Product description9-Aminocamptothecin
  • Packaging250mg
  • Price$1678
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA432426
  • Product description9-Aminocamptothecin 97%
  • Packaging2mg
  • Price$25
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA432426
  • Product description9-Aminocamptothecin 97%
  • Packaging5mg
  • Price$41
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA432426
  • Product description9-Aminocamptothecin 97%
  • Packaging10mg
  • Price$69
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA432426
  • Product description9-Aminocamptothecin 97%
  • Packaging25mg
  • Price$116
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0028201
  • Product description9-AMINO-CAMPTOTHECIN 95.00%
  • Packaging10MG
  • Price$700.36
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0028201
  • Product description9-AMINO-CAMPTOTHECIN 95.00%
  • Packaging25MG
  • Price$867.96
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0028201
  • Product description9-AMINO-CAMPTOTHECIN 95.00%
  • Packaging50MG
  • Price$1082.74
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberC5790
  • Product description9-aminoCamptothecin
  • Packaging5mg
  • Price$158
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberC5790
  • Product description9-aminoCamptothecin
  • Packaging10mg
  • Price$208
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberC5790
  • Product description9-aminoCamptothecin
  • Packaging25mg
  • Price$435
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN90309
  • Product description9-Aminocamptothecin
  • Packaging20mg
  • Price$128
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberSY058008
  • Product description9-Aminocamptothecin ≥95%
  • Packaging10mg
  • Price$136.36
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS013668
  • Product description9-Aminocamptothecin 97%
  • Packaging25mg
  • Price$173
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2506
  • Product description9-Aminocamptothecin
  • Packaging250mg
  • Price$975
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific K664 9-Aminocamptothecin 10mg $97 2021-12-16 Buy
AK Scientific K664 9-Aminocamptothecin 250mg $1678 2021-12-16 Buy
Ambeed A432426 9-Aminocamptothecin 97% 2mg $25 2021-12-16 Buy
Ambeed A432426 9-Aminocamptothecin 97% 5mg $41 2021-12-16 Buy
Ambeed A432426 9-Aminocamptothecin 97% 10mg $69 2021-12-16 Buy
Ambeed A432426 9-Aminocamptothecin 97% 25mg $116 2021-12-16 Buy
American Custom Chemicals Corporation CHM0028201 9-AMINO-CAMPTOTHECIN 95.00% 10MG $700.36 2021-12-16 Buy
American Custom Chemicals Corporation CHM0028201 9-AMINO-CAMPTOTHECIN 95.00% 25MG $867.96 2021-12-16 Buy
American Custom Chemicals Corporation CHM0028201 9-AMINO-CAMPTOTHECIN 95.00% 50MG $1082.74 2021-12-16 Buy
ApexBio Technology C5790 9-aminoCamptothecin 5mg $158 2021-12-16 Buy
ApexBio Technology C5790 9-aminoCamptothecin 10mg $208 2021-12-16 Buy
ApexBio Technology C5790 9-aminoCamptothecin 25mg $435 2021-12-16 Buy
Arctom CFN90309 9-Aminocamptothecin 20mg $128 2021-12-16 Buy
Arctom SY058008 9-Aminocamptothecin ≥95% 10mg $136.36 2021-12-16 Buy
Arctom AS013668 9-Aminocamptothecin 97% 25mg $173 2021-12-16 Buy
AvaChem 2506 9-Aminocamptothecin 250mg $975 2021-12-16 Buy

Properties

Melting point :142.0-145.0 °C
Boiling point :819.6±65.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form :powder to crystal
pka :11.23±0.20(Predicted)
color :Light yellow to Yellow to Orange
Merck :14,431
InChIKey :FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference :91421-43-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. 9-amino Camptothecin is a topoisomerase I inhibitor that was developed as a more water-soluble analog of camptothecin . It is cytotoxic to HT-29 cells at an IC50 value of 19 nM, induces DNA damage in whole cells at a concentration of 85 nM, and demonstrates significant anti-tumor activity in clinical studies.

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