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9-Aminocamptothecin

9-Aminocamptothecin structure

CAS No.: 91421-43-1

Chemical Name:: 9-Aminocamptothecin

Synonyms: NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin

CBNumber:: CB5125434

Molecular Formula:: C20H17N3O4

Molecular Weight:: 363.37

MDL Number:: MFCD00909855

MOL File:: 91421-43-1.mol

MSDS File:: SDS

Last updated:2023-09-04 15:51:00

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9-Aminocamptothecin Properties

Melting point	142.0-145.0 °C
Boiling point	819.6±65.0 °C(Predicted)
Density	1.55±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form	powder to crystal
pka	11.23±0.20(Predicted)
color	Light yellow to Yellow to Orange
Merck	14,431
InChIKey	FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference	91421-43-1(CAS DataBase Reference)
FDA UNII	5MB77ICE2Q
NCI Dictionary of Cancer Terms	aminocamptothecin
NCI Drug Dictionary	aminocamptothecin

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

RTECS

UQ0490500

HS Code

29349990

NFPA 704

	0
2		0

9-Aminocamptothecin price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2063	9-Aminocamptothecin >95.0%(HPLC)	91421-43-1	10mg	$485	2024-03-01	Buy
Cayman Chemical	17232	9-amino Camptothecin ≥95%	91421-43-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	17232	9-amino Camptothecin ≥95%	91421-43-1	5mg	$139	2024-03-01	Buy
Cayman Chemical	17232	9-amino Camptothecin ≥95%	91421-43-1	10mg	$184	2024-03-01	Buy
Cayman Chemical	17232	9-amino Camptothecin ≥95%	91421-43-1	25mg	$381	2024-03-01	Buy

Product number	Packaging	Price	Buy
A2063	10mg	$485	Buy
17232	1mg	$32	Buy
17232	5mg	$139	Buy
17232	10mg	$184	Buy
17232	25mg	$381	Buy

9-Aminocamptothecin Chemical Properties,Uses,Production

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

9-Aminocamptothecin Suppliers

Global( 200)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8348	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu GLP biotechnology Co Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Shochem(Shanghai) Co.,Ltd	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 9-Aminocamptothecin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-10-14	9-Aminocamptothecin 91421-43-1	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2020-07-27	9-Aminocamptothecin 91421-43-1	US $0.00-0.00 / g	1g	95%	1kg/month	Shochem(Shanghai) Co.,Ltd
2020-01-01	9-Aminocamptothecin 91421-43-1	US $1.00 / KG	1KG	99%	10000KGS	Career Henan Chemical Co

9-Aminocamptothecin
91421-43-1
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

9-Aminocamptothecin
91421-43-1
US $0.00-0.00 / g
95%
Shochem(Shanghai) Co.,Ltd

9-Aminocamptothecin
91421-43-1
US $1.00 / KG
99%
Career Henan Chemical Co

9-Aminocamptothecin Spectrum

9-Aminocamptothecin(91421-43-1)¹HNMR

91421-43-1(9-Aminocamptothecin)Related Search:

10-Hydroxycamptothecin Glycine Betaine (+)-Camptothecin ALTRENOGEST

4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Rubitecan 9-methoxy-7-ethylcamptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Camptothecin

20R-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin 9-amino-20-camptothecin

Hydroxyl camptothecine AMINO ACIDS 9-Aminocamptothecin

1of4

4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)- CAMPTOTHECIN, 9-AMINO-(RG) (S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di CAMPTOTHECIN, 9-AMINO- AMinocaMptothecin 9-AMINO-CAMPTOTHECIN 9-Amino-20-(S)-camptothecin 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione (20S)-9-AMINOCAMPTOTHECIN 9-Aminocamptothecin，9-Amino-20-(S)-camptothecin (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione 9-Amino-20(S)-camptothecine NSC-603071 (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3 1H-Pyrano(3 9-Aminocamptothecin, >96% 2-aminobenzoic acid [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]-3-oxolanyl] ester 9-Aminocamptothecin, 98%, from the fruit of Camptotheca acuminata Decne. 9-Aminocamptothecin > 9-amino-2(S)-camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)- Camptothecin Impurity 14 91421-43-1 C20H17N3O4 Pharmaceutical Raw Materials Alkaloids Natural Anti-cancer Medical Materials and It's Derivatives