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ChemicalBook >> CAS DataBase List >> SB218078

SB218078

SB218078 price.
  • $140 - $1700
  • Product name: SB218078
  • CAS: 135897-06-2
  • MF: C24H15N3O3
  • MW: 393.39
  • EINECS:
  • MDL Number:MFCD27991263
  • Synonyms:9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione;SB218078 ?SB-218078;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-
Price11 Properties Safety Information Description
11 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1MG
  • 2.5mg
  • 5mg
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000224
  • Product descriptionSB-218078 95.00%
  • Packaging1MG
  • Price$648.83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3012
  • Product descriptionSB218078
  • Packaging1mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13335
  • Product descriptionSB 218078 ≥98%
  • Packaging1mg
  • Price$141
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028421
  • Product descriptionSB-218078 ≥98.0%
  • Packaging1mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028421
  • Product descriptionSB-218078 ≥98.0%
  • Packaging5mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN21202
  • Product descriptionSB218078
  • Packaging1mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN21202
  • Product descriptionSB218078
  • Packaging5mg
  • Price$353
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9924
  • Product descriptionSB218078 >98%
  • Packaging250mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9924
  • Product descriptionSB218078 >98%
  • Packaging1g
  • Price$1700
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number559402
  • Product descriptionSB 218078 - CAS 135897-06-2 - Calbiochem
  • Packaging1mg
  • Price$223
  • Updated2023-01-07
  • Buy
  • ManufacturerTRC
  • Product numberS155068
  • Product descriptionSB218078
  • Packaging2.5mg
  • Price$160
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0000224 SB-218078 95.00% 1MG $648.83 2021-12-16 Buy
ApexBio Technology C3012 SB218078 1mg $160 2021-12-16 Buy
Cayman Chemical 13335 SB 218078 ≥98% 1mg $141 2024-03-01 Buy
ChemScene CS-0028421 SB-218078 ≥98.0% 1mg $150 2021-12-16 Buy
ChemScene CS-0028421 SB-218078 ≥98.0% 5mg $380 2021-12-16 Buy
CSNpharm CSN21202 SB218078 1mg $140 2021-12-16 Buy
CSNpharm CSN21202 SB218078 5mg $353 2021-12-16 Buy
DC Chemicals DC9924 SB218078 >98% 250mg $850 2021-12-16 Buy
DC Chemicals DC9924 SB218078 >98% 1g $1700 2021-12-16 Buy
Sigma-Aldrich 559402 SB 218078 - CAS 135897-06-2 - Calbiochem 1mg $223 2023-01-07 Buy
TRC S155068 SB218078 2.5mg $160 2021-12-16 Buy

Properties

Melting point :>340 °C
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.

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Aladdin Scientific 3B Pharmachem (Wuhan) International Co.,Ltd. Spectrum Chemical Manufacturing Corp. Sichuan Wei Keqi Biological Technology Co., Ltd. AdooQ Bioscience CHINA EMMX Biotechnology LLC Beijing Jin Ming Biotechnology Co., Ltd.