| | 7272-84-6 Basic information More.. |
| Product Name: | 3-(4-Pyridyl)indole | | Synonyms: | 3-(4-Pyridinyl)-;Rho Kinase Inhibitor III, Rockout;1H-Indole, 3-(4-pyridinyl)-;3-(4-Pyridinyl)-1H-indole;3-(4-Pyridyl)indole;Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem;Rho Kinase Inhibitor III;RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT | | CAS: | 7272-84-6 | | MF: | C13H10N2 | | MW: | 194.23 | | EINECS: | | | Mol File: | 7272-84-6.mol |  |
Use
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]
- 3-(4-Pyridyl)indole
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- US $0.37 / g
- 2021-01-06
- CAS:7272-84-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 10kg,100kg Cherry 0956
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7272-84-6
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