| | 108612-45-9 Basic information More.. |
| Product Name: | Mizolastine | | Synonyms: | 4(1h)-pyrimidinone,2-((1-(1-((4-fluorophenyl)methyl)-1h-benzimidazol-2-yl)-4-p;iperidinyl)methylamino)-;2-[[1-[1-[(4-fluorophenyl)methyl]benzoimidazol-2-yl]-4-piperidyl]-methyl-amino]-3h-pyrimidin-4-one;MIZOLASTINE;2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(1H)-pyrimidinone;Mizolastine HCl;2-[[1-[1-(4-fluorobenzyl)benzimidazol-2-yl]-4-piperidyl]-methyl-amino]-1H-pyrimidin-6-one;2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methyl-amino]-1H-pyrimidin-6-one | | CAS: | 108612-45-9 | | MF: | C24H25FN6O | | MW: | 432.49 | | EINECS: | 1308068-626-2 | | Mol File: | 108612-45-9.mol |  |
Use
Mizolastine was marketed in Germany and Switzerland as Mizollen for
the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and
urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with
a rapid onset of action ; the two most recent H1 antagonists launched were
fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine
(Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1-
(4-fluorobenzyl)benzimidazole by successive condensations of appropriate
amine and thioether. Mizolastine selectively blocks the peripheral H1 receptors
(but not the serotonergic, noradrenergic, muscarinic receptors) with a minimal
occupancy of brain receptors, and therefore does not elicit any sedative effects.
Moreover, Mizolastine does not produce cardiac rhythm disorders which have
been associated with certain non-sedating antihistamines in humans.
- Mizolastine
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- US $0.00 / kg
- 2023-09-21
- CAS:108612-45-9
- Min. Order: 1kg
- Purity: 98.0 ~ 102%
- Supply Ability: 20tons
- Mizolastine
-
- US $100.00 / kg
- 2023-08-02
- CAS:108612-45-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000tons
- Mizolastine
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- US $1000.00 / KG
- 2021-10-20
- CAS:108612-45-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 9000kg/per week
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108612-45-9
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