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| | (S)-(-)-2-Methyl-2-propanesulfinamide Basic information | | Description |
| | (S)-(-)-2-Methyl-2-propanesulfinamide Chemical Properties |
| Melting point | 97-101 °C(lit.) | | alpha | -4.5 º (c=1, CHCl3) | | Boiling point | 220.0±23.0 °C(Predicted) | | density | 1.124 | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 10.11±0.50(Predicted) | | form | Crystalline Powder | | color | White | | optical activity | [α]20/D 4.5°, c = 1 in chloroform | | Stability: | store cold | | InChI | InChI=1/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3/t7-/s3 | | InChIKey | CESUXLKAADQNTB-SSDOTTSWSA-N | | SMILES | CC(C)([S@@](N)=O)C |&1:3,r| | | CAS DataBase Reference | 343338-28-3(CAS DataBase Reference) |
| | (S)-(-)-2-Methyl-2-propanesulfinamide Usage And Synthesis |
| Description | Acid labile protecting groups are important in organic synthesis. The
tert‐butyl group is commonly used for protection of a large variety of
functional groups, e.g., acids, alcohols, phenols, and sulfonamides.
Among them, s-tert-butyl sulfonamide is a chiral ligand used in
pharmaceutical compositions. P, n-sulfoxide imine ligands were
synthesized by condensation of s-tert-butylsulfonamide with aldehydes
and ketones, and they can be used for asymmetric hydrogenation of
olefins under iridium catalysis. | | Physical properties | white to light yellow crystal powder | | Uses | (S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents. It may also be used to prepare (20E)-N-[t-butyl-(S)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the preparation of androgen receptor antagonists. | | Uses | (S)-(-)-2-Methyl-2-propanesulfinamide is used in Suzuki reaction. It is also employed as a reagent for synthesizing chiral amines. It acts as a chiral auxiliary used in an asymmetric synthesis of trifluoroethylamines by conversion of trifluoroacetaldehyde to a chiral imine. It is also involved in the transformation of P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. Further, it serves as a reagent for the preparation of chemicals and pharmaceutical intermediates. |
| | (S)-(-)-2-Methyl-2-propanesulfinamide Preparation Products And Raw materials |
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