- KM 11060
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- $1.00 / 1g
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2019-12-24
- CAS:774549-97-2
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| | KM 11060 Basic information |
| Product Name: | KM 11060 | | Synonyms: | 7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE;7-CHLORO-4-[4-[4-CHLOROPHENYL)SULFONYL]-1-PIPERAZINYL]QUINOLINE;KM 11060;CFTR-F508del Corrector, KM11060;KM11060;KM-11060;Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-;KM 11060,inhibit,KM11060,Inhibitor,Autophagy,Cystic fibrosis transmembrane conductance regulator,CFTR,KM-11060 | | CAS: | 774549-97-2 | | MF: | C19H17Cl2N3O2S | | MW: | 422.33 | | EINECS: | | | Product Categories: | | | Mol File: | 774549-97-2.mol |  |
| | KM 11060 Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol | | form | Powder |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 |
| | KM 11060 Usage And Synthesis |
| Uses | KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics. | | Biological Activity | Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity. |
| | KM 11060 Preparation Products And Raw materials |
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