- WS-12
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- $20.00/ kg
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2024-05-27
- CAS:68489-09-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000 tons
- Cooling agent WS-12
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- $18.00 / 10kg
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2024-05-10
- CAS:68489-09-8
- Min. Order: 1kg
- Purity: 99.9
- Supply Ability: 5000
- Cooling agent WS-12
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- $25.00/ kg
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2024-04-25
- CAS:68489-09-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000kg/week
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| Product Name: | WS 12 | | Synonyms: | WS 12;(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide;CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)-;(2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide;(1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE;Cooling agent WS12;(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide;Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)- | | CAS: | 68489-09-8 | | MF: | C18H27NO2 | | MW: | 289.41 | | EINECS: | 700-232-9 | | Product Categories: | | | Mol File: | 68489-09-8.mol |  |
| | WS 12 Chemical Properties |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 53-61 | | RIDADR | UN 3077 9 / PGIII |
| | WS 12 Usage And Synthesis |
| Description | WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice. | | Chemical Properties | WS 12 is a odorless white crystalline solid,mp 178 °C, displaying
a strong initial cooling effect and a long-lastingness. It is used particularly is oral
care flavors. | | Uses | WS 12 is a potent TRPM8 agonist. | | Trade name | Winsense WS-12 (Renessenz) | | Biological Activity | Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM). | | Biochem/physiol Actions | WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer. | | storage | Store at -20°C |
| | WS 12 Preparation Products And Raw materials |
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