肿瘤归巢肽LYP-1
| 中文名称 | 肿瘤归巢肽LYP-1 |
|---|---|
| 中文同义词 | 肿瘤归巢肽LYP-1 |
| 英文名称 | L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide |
| 英文同义词 | L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide |
| CAS号 | 454487-07-1 |
| 分子式 | C36H65N17O12S2 |
| 分子量 | 992.14 |
| EINECS号 | |
| 相关类别 | 目录肽 |
| Mol文件 | 454487-07-1.mol |
| 结构式 |  |
肿瘤归巢肽LYP-1 性质
| 密度 | 1.65±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 2.95±0.70(Predicted) |
LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide.The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×10 6 photon/cm 2 /sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide.