- Febrifugine
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- $9.80 / 1KG
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2020-01-10
- CAS:24159-07-7
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 20 tons
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| | Febrifugine Basic information |
| Product Name: | Febrifugine | | Synonyms: | Febrifugine;β-dichroine;3-(3-(3-Hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one;Febrifugine，Isofebrifugine;3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone;BETA-Febrifugine;febrifugin;4(3H)-Quinazolinone, 3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]- | | CAS: | 24159-07-7 | | MF: | C16H19N3O3 | | MW: | 301.34 | | EINECS: | | | Product Categories: | | | Mol File: | 24159-07-7.mol |  |
| | Febrifugine Chemical Properties |
| Melting point | 139-140°; mp 154-156° | | alpha | D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol) | | density | 1.39 | | storage temp. | 2-8°C | | solubility | DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml | | form | A crystalline solid | | Boiling point | 508.2±60.0 °C(Predicted) | | pKa | 14.61±0.40(Predicted) | | CAS DataBase Reference | 24159-07-7 |
| Toxicity | LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949) |
| | Febrifugine Usage And Synthesis |
| Description | Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection. | | Uses | Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis. |
| | Febrifugine Preparation Products And Raw materials |
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