| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Package:10Mg,1Mg
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Purity:> 95% Remarks:8-Hydroxy Loxapine is the inactive metabolite of Loxapine.
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:8-Hydroxy Loxapine
CAS:61443-77-4
Purity:>95%
|
|
| | 8-hydroxyloxapine Basic information |
| | 8-hydroxyloxapine Chemical Properties |
| Melting point | 212-215°C | | storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO: soluble | | form | A solid | | Stability: | Light Sensitive |
| | 8-hydroxyloxapine Usage And Synthesis |
| Description | 8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets). | | Chemical Properties | Pale Yellow Solid | | Uses | The inactive |
| | 8-hydroxyloxapine Preparation Products And Raw materials |
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