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| | 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Basic information |
| Product Name: | 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate | | Synonyms: | Trifluoromethanesulfonic acid 2-[[(tert-butyl)dimethylsilyl]oxy]ethyl ester;2-(t-ButyldiMethylsilyl)oxyethyl triflate;Methanesulfonicacid,1,1,1-trifluoro-,2-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethylester;2-(t-Butyldimethylsilyloxy)EthylTrifluoromethanesulfonate;2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate;2-(tert-butyldiMethylsilyloxy)ethyl trifluoroMethanesulfonate;1,1,1-Trifluoromethanesulfonic acid 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl ester;2-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}ethyl trifluoromethanesulfonate | | CAS: | 164162-36-1 | | MF: | C9H19F3O4SSi | | MW: | 308.39 | | EINECS: | | | Product Categories: | | | Mol File: | 164162-36-1.mol |  |
| | 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Chemical Properties |
| Boiling point | 253℃ | | density | 1.172 | | Fp | 107℃ |
| | 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Usage And Synthesis |
| Uses | 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 
The reaction was carried out under a nitrogen atmosphere. TBS- ethylene glycol prepared as per step 1 (85.10g, 0.48 mol) and 2, 6-Lutidine (84.28ml, 0.72 mol) were stirred in n-heptane (425ml) to give a clear solution which was then cooled to -15 to - 25°C. Trifluoromethanesulfonic anhydride (Tf2O) (99.74 ml, 0.590 mol) was added drop-wise over a period of 45 minutes to the n-heptane solution (white precipitate starts to form immediately) while maintaining the reaction at -15 to -25°C. The reaction mixture was kept at temperature between -15 to -25°C for 2 hours. The precipitate generated was filtered off. The filtrate was then evaporated up to ~2 volumes with respect to TBS-ethyiene glycol (~200 ml). |
| | 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Preparation Products And Raw materials |
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