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ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

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16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Suppliers list
Company Name: BIONNA MEDICINE CO.,LTD
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Products Intro: Product Name:16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
CAS:77017-20-0
Purity:0.99 Package:500g；1kg
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
CAS:77017-20-0
Purity:Above 98% / Summer 618 Package:1g;9USD
Company Name: ZHEJIANG JIUZHOU CHEM CO., LTD
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Products Intro: Product Name:16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
CAS:77017-20-0
Package:1KG
Company Name: Wuhan Cell Pharmaceutical Co., Ltd
Tel: +86-13129979210 +86-13129979210
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Products Intro: Product Name:DIOL
CAS:77017-20-0
Purity:99% Package:1KG;1USD
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Products Intro: Product Name:Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate
CAS:77017-20-0
Purity:NTL 99％; IH;Supply Ability: 3 tons/ year Package:5KG;USD|25KG;USD|500KG;USD
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Basic information
Product Name:16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
Synonyms:16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;16-alpha,17-alpha-dihydroxy-3,20-dioxopregna- 1,4,9(11)-trien-21-yl acetate;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione;BNKY015-BD01;Budesonide Impurity 12
CAS:77017-20-0
MF:C23H28O6
MW:400.46482
EINECS:278-593-2
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:77017-20-0.mol
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Structure
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties
Melting point 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
Boiling point 576.7±50.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
solubility soluble in Acetone, Dichloromethane
pka11.92±0.70(Predicted)
Water Solubility 38.72mg/L at 25℃
LogP2.26 at 25℃
Safety Information
MSDS Information
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Usage And Synthesis
UsesIntermediate in the preparation of antiinflammatory compounds.
Synthesis2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials
Raw materials3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
Preparation ProductsPrednisone Impurity 13
Tag:16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate(77017-20-0) Related Product Information
Budesonide Impurity 30 Prednisone 17, 21-Diacetate 11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione Budesonide Impurity 11 Budesonide Impurity 7 21-Dehydro Budesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) (11β,16α)-21-(Acetyloxy)-11,16,17-trihydroxypregna-1,4,14-triene-3,20-dione 11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate GOJZZYSAJXCRGI-KXGXINSVSA-N 16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Budesonide iMpurity Budesonide Impurity (1, 4-Androstadien-11-beta-16-alfa-diol-3, 17-dione) Budesonide Impurity 6 21-Dehydro-16α-hydroxy Prednisolone 2,4,6-tripropyl-1,3,5-trioxane Budesonide (r)-budesonide