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J & K SCIENTIFIC LTD.
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| Products Intro: |
Product Name:Dibenzepin
CAS:4498-32-2
Package:50Mg,5Mg
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| | Dibenzepin Basic information |
| Product Name: | Dibenzepin | | Synonyms: | 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one;5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine;HF 1927;Dibenzepin;10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one;10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one;5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one;4498-32-12 | | CAS: | 4498-32-2 | | MF: | C18H21N3O | | MW: | 295.38 | | EINECS: | | | Product Categories: | Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 4498-32-2.mol |  |
| | Dibenzepin Chemical Properties |
| Melting point | 116-117°C | | Boiling point | bp0.01 185° | | density | 1.1190 (rough estimate) | | refractive index | 1.5855 (estimate) | | storage temp. | Refrigerator | | solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) | | pka | 8.25(at 25℃) | | form | Solid | | color | Light Beige to Brown | | CAS DataBase Reference | 4498-32-2 |
| RIDADR | 3249 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | Dibenzepin Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Originator | Noveril ,Wander,Switz.,1965 | | Uses | Antidepressant | | Definition | ChEBI: 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone is a dibenzodiazepine. | | Manufacturing Process | 4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane.
After adding a concentrated benzenic solution of β-dimethylamino-ethyl
chloride freshly prepared from 3.75 grams of the hydrochloride with
concentrated sodium hydroxide solution, taking up in benzene and drying the
solution with potash, the mixture was boiled for 16 hours under reflux,
whereupon the reaction mixture was concentrated to dryness and the residue
distributed between ether and water. By exhaustive extraction of the basic
fractions with dilute acetic acid, precipitation with ammonia, taking up the
base in ether and working up the ethereal solution, there was obtained 5.05
grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11-
dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous
yellowish resin with the boiling point 185°C/0.01mm Hg. The base was
crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of
the monohydrochloride (from ethanol-ether) 234°-240°C. | | Therapeutic Function | Psychostimulant |
| | Dibenzepin Preparation Products And Raw materials |
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