| Company Name: |
Zhengzhou Alpha Chemical Co. LTD
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0371-0371-53732842 13383863444 |
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3002612166@qq.com |
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Product Name:Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
CAS:22200-69-7
Purity:98% Package:1g；5g；10g；25g；50g；100g；250g；500g；1kg，5kg
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| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
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sales@focusbiomolecules.com |
| Products Intro: |
Product Name:Seriniquinone
CAS:22200-69-7
Purity:98% by TLCNMR (Conforms) Package:$60.00/1mg;$180.00/5mg;
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| | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Basic information |
| Product Name: | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone | | Synonyms: | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone;Seriniquinone | | CAS: | 22200-69-7 | | MF: | C20H8O4S | | MW: | 344.34 | | EINECS: | | | Product Categories: | | | Mol File: | 22200-69-7.mol | ![Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Structure](CAS/20200611/GIF/22200-69-7.gif) |
| | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Chemical Properties |
| Melting point | 288 °C | | Boiling point | 612.3±54.0 °C(Predicted) | | density | 1.578±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml) | | form | solid | | color | Orange | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
| | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Usage And Synthesis |
| Description | Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1 | | Uses | Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells. | | References | 1) Trzoss?et al. (2014),?Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA,?111?14687 |
| | Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Preparation Products And Raw materials |
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