| Company Name: |
Chengdu Push Bio-Technology Co., Ltd.
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| Tel: |
028-85370565-229 18080489829 |
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3004654993@qq.com |
| Products Intro: |
Product Name:Manzamine A
CAS:104196-68-1
Purity:98% Package:5mg
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| | MANZAMINE A Basic information |
| Product Name: | MANZAMINE A | | Synonyms: | MANZAMINE A;1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-;Keramamine A | | CAS: | 104196-68-1 | | MF: | C36H44N4O | | MW: | 548.76 | | EINECS: | | | Product Categories: | | | Mol File: | 104196-68-1.mol |  |
| | MANZAMINE A Chemical Properties |
| Boiling point | 756.6±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (up to 25 mg/ml). | | pka | 13.58±0.40(Predicted) | | form | Off white to yellow solid. | | color | Off-White to Pale Yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | MANZAMINE A Usage And Synthesis |
| Description | Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4. | | Uses | Manzamine A is a β-Carboline alkaloid with anti-inflammatory. | | Definition | ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). | | storage | +4°C | | References | 1) Kallifatidis?et al. (2013),?The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs,?11?3500
2) Eguchi?et al. (2013),?Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem.,?21?3831
3) Zhang?et al. (2008),?Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull.,?56?866
4) Hamann?et al. (2007),?Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease; J. Nat. Prod.,?70 139 |
| | MANZAMINE A Preparation Products And Raw materials |
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