食欲肽B (人)
| 中文名称 | 食欲肽B (人) |
|---|---|
| 中文同义词 | 食欲肽B(人) ≥98%;食欲肽B (人);食欲肽B(人) ≥98%, ≥98% (HPLC);人OREXIN B;RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 (TRIFLUOROACETATE SALT);食欲素B(人类)三氟乙酸盐 |
| 英文名称 | OREXIN B (HUMAN) |
| 英文同义词 | REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2;Orexin B (huMan) Hypocretin-2 (huMan);OREXIN B HUMAN ≥98%;ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-2;HYPOCRETIN-2, HUMAN;H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
| CAS号 | 205640-91-1 |
| 分子式 | C123H212N44O35S |
| 分子量 | 2899.34 |
| EINECS号 | |
| 相关类别 | 生化试剂;多肽;其他生化试剂;标准品;proteins;Peptide;Orexin receptor |
| Mol文件 | 205640-91-1.mol |
| 结构式 |  |
食欲肽B (人) 性质
| 密度 | 1.49±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 水溶解性 | Soluble to 1 mg/ml in Water |
| 序列 | H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
Ki: 420 nM (OX1), 36 nM (OX2)
Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.
Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 2937190000 |
| 提供商 | 语言 |
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英文
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