butizide

butizide Suppliers list
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
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Email: sales@chemhifuture.com
Products Intro: Product Name:Buthiazide
CAS:2043-38-1
Purity:0.98 Package:5mg,10mg,100mg,500mg,1g,5g,10g
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Buthiazide;S 3500;Butizidum;S-3500;Saltucin;Eunephran
CAS:2043-38-1
Package:1 g;100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Meike meditech (Foshan) Co.,Ltd
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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
Purity:97% Package:1g/10g/25g/100g/500g/1kg
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
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Products Intro: CAS:2043-38-1
Purity:0.99 Package:5KG;1KG
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
Package:2.5g,250Mg
butizide Basic information
Product Name:butizide
Synonyms:6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide;butizide;Buthiazide;Thiabutazide;Eunephran;S-3500;Saltucin;Su-6187
CAS:2043-38-1
MF:C11H16ClN3O4S2
MW:353.85
EINECS:218-048-8
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:2043-38-1.mol
butizide Structure
butizide Chemical Properties
Melting point 214-217°C
Boiling point 562.7±60.0 °C(Predicted)
density 1.4221 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.01±0.40(Predicted)
color White to Yellow
Safety Information
MSDS Information
butizide Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorSaltucin,Boehringer Mannheim,W. Germany,1961
UsesDiuretic and antihypertensive.
DefinitionChEBI: Butizide is a benzothiadiazine.
Manufacturing ProcessChlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.
Therapeutic FunctionDiuretic, Antihypertensive
butizide Preparation Products And Raw materials
Raw materialsAmmonia-->3-Chloroaniline-->Chlorosulfonic acid-->Isovaleraldehyde
Tag:butizide(2043-38-1) Related Product Information
Propantheline bromide mebutizide butizide CYCLOTHIAZIDE Cyclopenthiazide 2-AMINO-N-BUTYLBENZENESULFONAMIDE Hydrochlorothiazide ethiazide 2-amino-N-propylbenzenesulfonamide