| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Buthiazide
CAS:2043-38-1
Package:2.5g,250Mg
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| | butizide Basic information |
| | butizide Chemical Properties |
| Melting point | 214-217°C | | Boiling point | 562.7±60.0 °C(Predicted) | | density | 1.4221 (rough estimate) | | refractive index | 1.6100 (estimate) | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 9.01±0.40(Predicted) | | color | White to Yellow |
| | butizide Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Originator | Saltucin,Boehringer Mannheim,W. Germany,1961 | | Uses | Diuretic and antihypertensive. | | Definition | ChEBI: Butizide is a benzothiadiazine. | | Manufacturing Process | Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C. | | Therapeutic Function | Diuretic, Antihypertensive |
| | butizide Preparation Products And Raw materials |
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