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| | 5-Aziridino-2,4-dinitrobenzamide Basic information |
| Product Name: | 5-Aziridino-2,4-dinitrobenzamide | | Synonyms: | 5-(1-aziridinyl)-2,4-dinitrobenzamide;NSC 115829;tretazicar;5-(1-Aziridinyl)-2,4-dinitrobenzamide, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide;5-Aziridino-2,4-dinitrobenzamide;2,4-Dinitro-5-(aziridine-1-yl)benzamide;CB-954;CB-1954 | | CAS: | 21919-05-1 | | MF: | C9H8N4O5 | | MW: | 252.18 | | EINECS: | | | Product Categories: | | | Mol File: | 21919-05-1.mol |  |
| | 5-Aziridino-2,4-dinitrobenzamide Chemical Properties |
| Melting point | 173 °C | | Boiling point | 427.2±45.0 °C(Predicted) | | density | 1.671±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | 14.23±0.50(Predicted) | | form | solid | | color | Yellow to Dark Yellow | | InChIKey | WOCXQMCIOTUMJV-UHFFFAOYSA-N |
| WGK Germany | 3 | | HS Code | 2933.99.7500 |
| | 5-Aziridino-2,4-dinitrobenzamide Usage And Synthesis |
| Description | CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent. | | Uses | 5-Aziridino-2,4-dinitrobenzamide is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2. | | Uses | Tretazicar is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2. | | Biochem/physiol Actions | CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2. |
| | 5-Aziridino-2,4-dinitrobenzamide Preparation Products And Raw materials |
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