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| | 1,4,8,11-TETRAAZACYCLOTETRADECANE Basic information |
| Product Name: | 1,4,8,11-TETRAAZACYCLOTETRADECANE | | Synonyms: | 1,4,8-Tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane;1,4,8-Tris(trifluoroacetyl)cyclaM;cyclaM, Methanol adduct;1,4,8,11-Tetraazacyclotetradecane 98% (GC);jm1498;CYCLAM;Cyclam, 98+%;1,4,8,11-TETRAAZACYCLOTETRADECANE | | CAS: | 295-37-4 | | MF: | C10H24N4 | | MW: | 200.32 | | EINECS: | 206-039-1 | | Product Categories: | Ring Systems;organic amine;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Azacrown Ethers;Crown Ethers;Functional Materials;Macrocycles for Host-Guest Chemistry;Achiral Nitrogen;Cy-N | | Mol File: | 295-37-4.mol |  |
| | 1,4,8,11-TETRAAZACYCLOTETRADECANE Chemical Properties |
| Melting point | 184-186 °C (lit.) | | Boiling point | 328.07°C (rough estimate) | | density | 1.0203 (rough estimate) | | refractive index | 1.5200 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Dichloromethane, Methanol | | form | Fluffy Needle-Like Crystalline Powder | | pka | 10.90±0.20(Predicted) | | color | White | | Water Solubility | Soluble in water. | | Sensitive | Air Sensitive | | BRN | 111811 | | InChIKey | MDAXKAUIABOHTD-UHFFFAOYSA-N | | CAS DataBase Reference | 295-37-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | XA5254800 | | F | 3-9-34 | | HS Code | 29339900 | | Toxicity | LD50 intraperitoneal in mouse: 371mg/kg |
| | 1,4,8,11-TETRAAZACYCLOTETRADECANE Usage And Synthesis |
| Chemical Properties | white fluffy needle-like crystalline powder | | Uses | Reagent used in the preparation of Plerixafor derivatives. | | Uses | 1,4,8,11-Tetraazacyclotetradecane is used in the synthesis of molecules with electroactive cavities. It acts as a nitrogen crown ether analogue and as an antioxidant in rubber. It is also used in the preparation of plerixafor derivatives. | | Uses | 1,4,8,11-Tetraazacyclotetradecane is macrocyclic ligand that is used as an antioxidant in rubber and has been shown to suppress oxidation catalyzed by some metal ions. | | Definition | ChEBI: 1,4,8,11-tetraazacyclotetradecane is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane. It derives from a hydride of a cyclotetradecane. | | General Description | 1,4,8,11-Tetraazacyclotetradecane is an azamacrocycle that forms more stable metal complexes as compared to open chain ligands. | | Purification Methods | Purify cyclam by recrystallisation from dioxane (white needles), and it sublimes above 120o. It has been distilled, b 132-140o/4-8mm. It forms complexes with metals and gives a sparingly soluble nitrate salt, m 205o(dec), which crystallises from H2O and is dried at 150o. [UV: Bosnich et al. Inorg Chem 4 1102 1963, van Alphen Recl Trav Chim Pays-Bas 56 343 1937, Beilstein 26 III/IV 1647.] |
| | 1,4,8,11-TETRAAZACYCLOTETRADECANE Preparation Products And Raw materials |
| Preparation Products | 1-[4,8-bis-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-yl]-2,2,2-trifluoroethanone, 1,4,8-tris(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane, 1,4,8-tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane, N,N',N''-tris(trifluoroace-->4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzaldehyde trihydrochloride |
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