| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Products Intro: |
Product Name:Zorubicin Hydrochloride
CAS:36508-71-1
Purity:Typically NLT 98%
|
| Company Name: |
ChemStrong Scientific Co.,Ltd
|
| Tel: |
0755-0755-66853366 13670046396 |
| Email: |
sales@chem-strong.com |
| Products Intro: |
Product Name:Zorubicin hydrochloride
CAS:36508-71-1
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
|
| Company Name: |
Jinan Renyuan Chemical Co., Ltd.
|
| Tel: |
0531-86128689 18396852370 |
| Email: |
1840274076@qq.com |
| Products Intro: |
Product Name: Daunorubicin hydrochloride
CAS:36508-71-1
Purity:99% Package:1G 10G 100G
|
|
| | ZORUBICIN HCL Basic information |
| Product Name: | ZORUBICIN HCL | | Synonyms: | ZORUBICIN HCL;22050r.p.;benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride;daunorubicin,benzoylhydrazone,monohydrochloride;nsc-164011;rp22,050hydrochloride;rubidaz;rubidazone,monohydrochloride | | CAS: | 36508-71-1 | | MF: | C34H36ClN3O10 | | MW: | 682.12 | | EINECS: | 253-076-4 | | Product Categories: | | | Mol File: | 36508-71-1.mol |  |
| | ZORUBICIN HCL Chemical Properties |
| alpha | D20 -50° (c = 0.2 in water) | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | Orange to Dark Red | | Stability: | Light Sensitive |
| Toxicity | LD50 in mice (mg/kg): 13.66 s.c., 4.42 i.p., 8.50 i.v. (Maral, 1972) |
| | ZORUBICIN HCL Usage And Synthesis |
| Originator | Zorubicin
Hydrochloride,ZYF Pharm
Chemical | | Uses | Antineoplastic. | | Uses | Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500). | | Manufacturing Process | 9.024 g daunorubicin-hydrochloride (its preparation and physicochemical
properties have been described in British Patent Specification No 985 598)
was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162
g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained
precipitate was filtered off, washed with 100 ml of ethanol and dried in
vacuum at 20°C. It was dissolved in water and small quantity of insoluble
product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6-
trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-
trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide
dihydrochloride (zorubicin) was obtained as red-orange crystalline powder;
[α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form
of different non-toxic salts such as benzoates, fumarates, maleates, tartrates
and so on. The best among these compounds proves to be daunorubicin
benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No.
1,578,722 published in 1967, Class CO7d). | | Therapeutic Function | Antineoplastic, Antileukemic |
| | ZORUBICIN HCL Preparation Products And Raw materials |
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