| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Guanoxan
CAS:2165-19-7
Package:100Mg,10Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:Guanoxan;(1,4-Benzodioxan-2-ylMethyl)guanidine; 2-(GuanidinoMethyl)-1,4-benzodioxan; Guanoxane; N-[(2,3-Dihydro-1,4-benzodioxin-2-yl)Methyl]guanidine
CAS:2165-19-7
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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- Guanoxan USP/EP/BP
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- $1.10 / 1g
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2021-08-11
- CAS:2165-19-7
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
- Guanoxan
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- $0.00 / 1KG
-
2020-05-10
- CAS:2165-19-7
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 500 MT
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| | Guanoxan Basic information |
| Product Name: | Guanoxan | | Synonyms: | 1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)guanidine;2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)guanidine;2-(GuanidinoMethyl)-1,4-benzodioxan;Guanoxane;N-[(2,3-Dihydro-1,4-benzodioxin-2-yl)Methyl]guanidine;Guanoxan;(1,4-Benzodioxan-2-ylmethyl)guanidine;Guanidine, N-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]- | | CAS: | 2165-19-7 | | MF: | C10H13N3O2 | | MW: | 207.23 | | EINECS: | | | Product Categories: | | | Mol File: | 2165-19-7.mol |  |
| | Guanoxan Chemical Properties |
| Melting point | 164-165° | | Boiling point | 339.3±45.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | pka | pKa 12.3 (Uncertain) |
| | Guanoxan Usage And Synthesis |
| Originator | Envacar,Pfizer | | Uses | Guanoxan is a sympatholytic drug related to Guanethidine (G815000). Guanoxan is used in the treatment of hypertension. | | Definition | ChEBI: Guanoxan is a benzodioxine. | | Manufacturing Process | 2 Methods of producing of 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine:
1. 3.3 parts by weight of 2-aminomethyl-1,4-benzodioxane and 2.78 parts by
weight of S-methylisothiouronium sulfate were dissolved in 20 parts by
volume of water, and the resulting aqueous solution was heated under reflux
for 3 h. At the end of this time, the solvent was removed by means of
evaporation under reduced pressure and the residue so obtained dissolved in
a minimum amount of fresh water and treated with charcoal. Upon filtration,
there was obtained a clear filtrate which, on standing, soon afforded pure
crystals of di(2-guanidinomethyl-1,4-benzodioxane)sulfate, melting point
204°-205°C.
The base 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine may be obtained
by reaction of di(2-guanidinomethyl-1,4-benzodioxane)sulfate with, for
example, sodium hydroxide.
2. o-Dihydroxybenzene reacted with epichlorhydrine in the presence sodium
hydroxide and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine was obtained.
To solution of 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine thionylchloride
was added to give 2-chlormethyl-2,3-dihydro-1,4-benzodioxine.
2-Chloromethyl-2,3-dihydro-1,4-benzodioxine reacted with benzylamine to
produced 2-benzylaminomethyl-2,3-dihydro-1,4-benzodioxine, which was
reduced at the presence of hydrogen and Pd-C (catalyst) to 2-aminomethyl-
2,3-dihydro-1,4-benzodioxine.
2-Aminomethyl-2,3-dihydro-1,4-benzodioxine was treated by Smethylisothiouronium sulfate and there was produced 2-guanidinemethyl-2,3-
dihydro-1,4-benzodioxine. | | Brand name | Envacar (Pfizer). | | Therapeutic Function | Antihypertensive |
| | Guanoxan Preparation Products And Raw materials |
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