- 2-Chloro-4-phenylquinazoline
-
- $200.00 / 1KG
-
2024-01-02
- CAS:29874-83-7
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-CHLORO-4-PHENYLQUINAZOLINE Basic information | | Uses |
| Product Name: | 2-CHLORO-4-PHENYLQUINAZOLINE | | Synonyms: | 2-CHLORO-4-PHENYLQUIZOLINE;Quinazoline,2-chloro-4-phenyl-;2-CHLORO-4-PHENYLQUINAZOLIN;oro-4-phenyL;quinazoL;2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001：2015 REACH;2-CHLORO-4-PHENYLQUINAZOLINE;2-Chloro-4-phenylq inazollne | | CAS: | 29874-83-7 | | MF: | C14H9ClN2 | | MW: | 240.69 | | EINECS: | 201-615-9 | | Product Categories: | quinazoline | | Mol File: | 29874-83-7.mol |  |
| | 2-CHLORO-4-PHENYLQUINAZOLINE Chemical Properties |
| Melting point | 113.0 to 117.0 °C | | Boiling point | 347.4±30.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | pka | 0.24±0.30(Predicted) | | color | White to Orange to Green |
| | 2-CHLORO-4-PHENYLQUINAZOLINE Usage And Synthesis |
| Uses | 2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators. | | Uses | 2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Uses | 2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators. | | Synthesis | 
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield). |
| | 2-CHLORO-4-PHENYLQUINAZOLINE Preparation Products And Raw materials |
|