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| | 3-AMINOPROPIONITRILE FUMARATE Basic information |
| | 3-AMINOPROPIONITRILE FUMARATE Chemical Properties |
| Hazard Codes | T | | Risk Statements | 61 | | Safety Statements | 53-45 | | WGK Germany | 3 | | RTECS | UG0700000 | | TSCA | Yes | | HS Code | 29269095 | | Toxicity | LDLo orl-rat: 800 mg/kg TJADAB 5,33,72 |
| | 3-AMINOPROPIONITRILE FUMARATE Usage And Synthesis |
| Chemical Properties | WHITE CRYSTALLINE POWDER | | Uses | 3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:
- to inhibit collagen cross-linking during microtissue formation and culture
- in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
- in lysyl oxidase (LOX) activity assay
- to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids
| | Definition | ChEBI: A fumarate salt prepared from beta-aminopropionitrile by reaction of one molecule of fumaric acid for every two molecules of beta-aminopropionitrile. | | Biochem/physiol Actions | 3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking. | | Safety Profile | Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO, and CN-. See also NITRILES. |
| | 3-AMINOPROPIONITRILE FUMARATE Preparation Products And Raw materials |
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