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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

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7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:7-Chlorokynurenic acid；7-CKA
CAS:18000-24-3
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
CAS:18000-24-3
Purity:99% Email: cherry@coreychem.com Package:1g;0.37USD
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:7-Chlorokynurenic acid
CAS:18000-24-3
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:7-Chlorokynurenic acid
CAS:18000-24-3
Purity:NLT 98% Remarks:MC533051
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:7-chloro-4-hydroxyquinoline-2-carboxylic acid
CAS:18000-24-3
Purity:97% Package:$565.9/100mg;$2547.9/500mg;$4584.9/1g;Bulk package Remarks:97%
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Basic information
Target
Product Name:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
Synonyms:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL;7-CHLOROKYNURENIC ACID;7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-CL-KYNA;7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-Chloroquinurenic acid;7-CKA
CAS:18000-24-3
MF:C10H6ClNO3
MW:223.61
EINECS:241-913-6
Product Categories:pharmacetical;Glutamate;Glutamate receptor
Mol File:18000-24-3.mol
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Structure
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Chemical Properties
Melting point 277-278 °C (decomp)
Boiling point 461.5±45.0 °C(Predicted)
density 1.600±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility 0.1 M NaOH: 13.7 mg/mL
form solid
pka0.90±0.30(Predicted)
color tan
CAS DataBase Reference18000-24-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Usage And Synthesis
Target Ki: 0.59 μM (reuptake of glutamate)    IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
UsesNMDA receptor antagonist at the glycine site
DefinitionChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Biological FunctionsGlycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biological ActivityNMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivoMale Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
storageRoom temperature
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Preparation Products And Raw materials
Tag:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL(18000-24-3) Related Product Information
Trichloroisocyanuric acid 5-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL 5,7-DICHLOROKYNURENIC ACID SODIUM SALT 5,7-DICHLORO-4-HYDROXY-QUINOLINE-2-CARBOXYLIC ACID ETHYL ESTER METHYL 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL DICHLOROKYNURENIC ACID, 5,7-[3-3H]-