4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	Product Name:1-NA-PP1 CAS:221243-82-9

Company Name:	BOC Sciences
Tel:	+1-631-485-4226
Email:	inquiry@bocsci.com
Products Intro:	Product Name:1-NA-PP1 CAS:221243-82-9 Package:25mg Remarks:BOC Sciences also provides custom synthesis services for 1-NA-PP1.

Company Name:	career henan chemical co
Tel:	+86-0371-86658258 15093356674;
Email:	factory@coreychem.com
Products Intro:	Product Name:4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE CAS:221243-82-9 Purity:>=99% Package:1.8KG;9.8USD

Company Name:	Zhejiang J&C Biological Technology Co.,Limited
Tel:	+1-2135480471 +1-2135480471
Email:	sales@sarms4muscle.com
Products Intro:	Product Name:1-NA-PP1 CAS:221243-82-9 Purity:99% Package:5KG;1KG Remarks:1-NA-PP1

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:1-Naphthyl PP1(1-NA-PP 1) CAS:221243-82-9 Purity:98% Package:5mg Remarks:V3630

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE manufacturers

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Basic information

Product Name:	4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
Synonyms:	4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE;1-NA-PP1;1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1-Naphthyl PP1;1-NAPHTHYL PP1(1-NA-PP 1);CS-2001;1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-
CAS:	221243-82-9
MF:	C19H19N5
MW:	317.39
EINECS:
Product Categories:	Other APIs;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Tyrosine Kinase Inhibitors;Intracellular Signaling
Mol File:	221243-82-9.mol

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Chemical Properties

Melting point	219-222°C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White

Safety Information

MSDS Information

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Usage And Synthesis

Chemical Properties	White Cyrstalline Solid
Uses	A highly potent (IC50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase
Definition	ChEBI: 1-NA-PP1 is a pyrazolopyrimidine. It has a role as a tyrosine kinase inhibitor.
Biological Activity	Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC 50 values are 1.0, 0.6, 0.6, 18 and 22 μ M for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC 50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Synthesis	Add 3-iodo-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine into a 250mL three-necked flask, dissolve in 300ml 10% Na2CO3, add 150ml dioxane, After cooling to 0 °C, Fmoc boronate was dissolved in 225 ml of acetone and added dropwise to the system. Stir at room temperature for 3h, pour into 1000ml of water, extract twice with ether, cool and adjust pH to about 2 with concentrated hydrochloric acid, extract with ethyl acetate (3×100ml), dry over MgSO4, evaporate the solvent, and rotate under reduced pressure. The crude product is subjected to silica gel column chromatography (V methanol: V dichloromethane=1:35) to give 4-amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-D] pyrimidine as a white crystal-like solid .
storage	+4°C

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Preparation Products And Raw materials

Tag:4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE(221243-82-9) Related Product Information

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