- PhosphoraMidon
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- $1.00 / 1KG
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2020-03-16
- CAS:119942-99-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 tons
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| | PHOSPHORAMIDON Basic information |
| | PHOSPHORAMIDON Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 1 mM Stock solution stable for 1 month at –20° C. | | form | Solid | | color | White to pale yellow | | BRN | 8105669 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months. |
| | PHOSPHORAMIDON Usage And Synthesis |
| Description | Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4 | | Uses | An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury. | | Uses | Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor. | | General Description | Phosphoramidon [N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomyces?tanashiensis. | | Biochem/physiol Actions | Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin. | | References | 1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183.
2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697
3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258
4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187 |
| | PHOSPHORAMIDON Preparation Products And Raw materials |
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